Treatment at Mayo Clinic

By Mayo Clinic Staff


Mayo Clinic accepts appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System sites.

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Treatment may not be necessary

If you don't have any signs or symptoms of sclerosing mesenteritis, you may not require treatment. Instead, your doctor may recommend periodic imaging tests to monitor your condition.

If you begin to experience signs and symptoms of sclerosing mesenteritis, you may choose to begin treatment.


Medications for sclerosing mesenteritis are intended to control inflammation. Medications may include:

  • Corticosteroids. Corticosteroids, such as prednisone, control inflammation. Corticosteroids can be used alone or in combination with other medications.
  • Hormone therapy. The hormone treatment tamoxifen may slow the growth of scar tissue. It may be combined with other medications.
  • Other drugs. Several other medications have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys), cyclophosphamide and thalidomide (Thalomid).


If your sclerosing mesenteritis advances to block the flow of food through your digestive system, surgery may be needed to remove the blockage.

March 22, 2014