Treatments and drugs

By Mayo Clinic Staff

Treatment for schizotypal personality disorder often includes a combination of medication and one or more types of psychotherapy.


There are no medications approved by the Food and Drug Administration for the treatment of schizotypal personality disorder. However, doctors may prescribe antipsychotic, antidepressant or anti-anxiety medications to help relieve certain symptoms, such as psychotic episodes, or related conditions, such as depression or anxiety. For example, prescription medications such as risperidone (Risperdal) or olanzapine (Zyprexa) may help reduce distorted thinking.


Psychotherapy, also called talk therapy, may help people with schizotypal personality disorder begin to trust others by building a trusting relationship with a therapist. Psychotherapy may include, for example, learning specific social skills and behaviors (behavior therapy) or identifying and changing distorted thought patterns (cognitive therapy).

Treatment can be more effective when family members are involved (family therapy). Seeking professional counseling as a group may help reduce fighting or emotional distance and improve trust in the home.

Improvement over time

Symptoms of conditions such as schizotypal personality disorder may improve over time. Factors that appear most likely to reduce the symptoms of this disorder include positive relationships with friends and family, as well as a sense of achievement at school, work and in extracurricular activities. These experiences may help foster — among other positive traits — confidence, a belief in one's ability to overcome difficulty and a sense of social support.

April 11, 2013