Can drinking mangosteen juice reduce arthritis inflammation and pain?
Answers from Brent A. Bauer, M.D.
It might. A number of laboratory and animal studies suggest that mangosteen has significant anti-inflammatory effects. And a few small-scale studies in humans indicate that the juice helps reduce blood levels of C-reactive protein (CRP). CRP is a substance associated with inflammation, which may be caused by widespread infection or disorders such as inflammatory bowel disease, lupus and rheumatoid arthritis.
But the studies that found this reduction in CRP were not conducted with people who have arthritis. And not everybody who has arthritis has elevated CRP. So at this point, while the data appears promising, it's too early to say what role mangosteen juice has in treating arthritis symptoms.
Mangosteen is a tropical fruit native to Southeast Asia. Despite its name, mangosteen is not related to the mango. The mangosteen fruit is the size and shape of a tangerine, with a thick, dark rind and creamy flesh. Mangosteen is marketed as a supplement, both as a juice and in capsule form.
Oct. 10, 2014
See more Expert Answers
- Mangosteen juice. American Cancer Society. http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/mangosteen-juice. Accessed July 21, 2014.
- Mangosteen. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed July 21, 2014.
- Chitchumroonchokchai C, et al. Xanthones in mangosteen juice are absorbed and partially conjugated in healthy adults. The Journal of Nutrition. 2012;142:675.
- Udani JK, et al. Evaluation of mangosteen juice blend on biomarkers of inflammation in obese subjects: A pilot, dose-finding study. Nutrition Journal. 2009;8:48.
- Tang YP, et al. Effect of a mangosteen dietary supplement on human immune function: A randomized, double-blind, placebo-controlled trial. Journal of Medicinal Food. 2009;12:755.