Risk factorsBy Mayo Clinic Staff
RLS/WED can develop at any age, even during childhood. The disorder is more common with increasing age and more common in women than in men.
Restless legs syndrome usually isn't related to a serious underlying medical problem. However, RLS/WED sometimes accompanies other conditions, such as:
Dec. 10, 2014
- Peripheral neuropathy. This damage to the nerves in your hands and feet is sometimes due to chronic diseases such as diabetes and alcoholism.
- Iron deficiency. Even without anemia, iron deficiency can cause or worsen RLS/WED. If you have a history of bleeding from your stomach or bowels, experience heavy menstrual periods or repeatedly donate blood, you may have iron deficiency.
- Kidney failure. If you have kidney failure, you may also have iron deficiency, often with anemia. When kidneys don't function properly, iron stores in your blood can decrease. This, with other changes in body chemistry, may cause or worsen RLS/WED.
- Restless legs syndrome. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm. Accessed Nov. 30, 2014.
- Tarsy D. Clinical manifestations and diagnosis of restless leg syndrome in adults. http://www.uptodate.com/home. Accessed Nov. 30, 2014.
- Tarsy D. Treatment of restless leg syndrome in adults. http://www.uptodate.com/home. Accessed Nov. 30, 2014.
- Garcia-Borreguero D, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: A report from the International Restless Legs Syndrome Study Group. Sleep Medicine. 2013;14:675.
- Silber, MH, et al. Willis-Ekbom Foundation revised consensus statement on the management of restless legs syndrome. Mayo Clinic Proceedings. 2013;88:977.