Often, there's no known cause for restless legs syndrome. Researchers suspect the condition may be due to an imbalance of the brain chemical dopamine, which sends messages to control muscle movement.
Sometimes RLS/WED runs in families, especially if the condition starts before age 50. Researchers have identified sites on the chromosomes where genes for RLS/WED may be present.
Pregnancy or hormonal changes may temporarily worsen RLS/WED signs and symptoms. Some women get RLS/WED for the first time during pregnancy, especially during their last trimester. However, signs and symptoms usually disappear after delivery.
Dec. 10, 2014
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- Tarsy D. Clinical manifestations and diagnosis of restless leg syndrome in adults. http://www.uptodate.com/home. Accessed Nov. 30, 2014.
- Tarsy D. Treatment of restless leg syndrome in adults. http://www.uptodate.com/home. Accessed Nov. 30, 2014.
- Garcia-Borreguero D, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: A report from the International Restless Legs Syndrome Study Group. Sleep Medicine. 2013;14:675.
- Silber, MH, et al. Willis-Ekbom Foundation revised consensus statement on the management of restless legs syndrome. Mayo Clinic Proceedings. 2013;88:977.