Below are current clinical trials.27 studies in Prostate cancer
(open studies only).
Filter this list of studies by location, status and more.
Eau Claire, Wis., La Crosse, Wis., Mankato, Minn., Albert Lea, Minn.
RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells. PURPOSE: This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.
The purpose of this study is to identify DNA methylation (genetic) markers in non-cancerous prostate tissue, and compare with the markers previously found to be in prostate cancer tissue. This will provide data that can be used to identify genetic marker profiles to diagnose and provide prognosis for prostate cancer.
Castration-resistant prostate cancer patients with rising prostatic specific antigen (PSA) are eligible for this study. 11C-Choline PET/CT will be used to identify metastatic lesions. Patients with <=3 metastatic lesions will receive stereotactic body radiotherapy (SBRT) as definitive treatment. Blood draws will be taken to monitor the development of anti-prostate cancer immunity
The primary purpose of this study is to evaluate the feasibility and safety of MRI-guided focal laser ablation (Laser-Induced Interstitial Thermal Therapy, LITT) to treat low-risk native prostate cancer.
We are studying whether men being treated for prostate cancer have the same amount of side effects from either one of two different external radiation treatments: IMRT or PBT. With IMRT, a number of x-ray beams are used to shape the radiation to the prostate. PBT is another type of external radiation treatment for prostate cancer that is used in a few centers in the United States. Protons are tiny particles with positive charge that can be controlled to travel a certain distance and stop. PBT is precise like IMRT, but it uses proton beams instead of x-ray beams. IMRT and PBT aim to deliver most of the radiation to the prostate cancer while sparing surrounding tissues. Both IMRT and PBT have been used in the treatment of prostate cancer and are thought to be equally effective at curing prostate cancer. However, both treatments have also been shown to cause the potential side effects of radiation, including bowel, urinary and erectile problems. It is possible that side effect rates with PBT will be lower, the same, or even higher than with IMRT, but this has not been studied well to date. Though both of these radiation therapies have been used in the past to treat prostate cancer, there has never been a study that compares the effects of these two therapies to see which one has less side effects. In this research study, we are comparing IMRT to PBT to determine which therapy best minimizes the side effects of treatment.
The goal of this study is to create and maintain a comprehensive genitourinary disease biospecimens bank consisting of tissue, kidney stones and bodily fluid (such as blood or urine, but not limited to this) samples.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla.
The goal of this clinical study is to determine the safety and efficacy of VT-464, a lyase-selective inhibitor of CYP17 and an androgen receptor antagonist, in patients with castration-resistant prostate cancer (CRPC) who have been previously treated with enzalutamide or abiraterone.
The purpose of this study is to compare the effects, good and/or bad of two treatment methods on subjects and their cancer. Proton beam radiation therapy is one of the treatments for men with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy (28 treatments) alone to proton therapy with androgen suppression therapy.
Many of the current imaging tests we have for prostate cancer are problematic in their ability to distinguish cancerous from non-cancerous prostate tissue. This study is being performed to develop better imaging techniques to better identify and characterize prostate cancer.
The purpose of this research is to see if MR-guided cryoablation can effectively treat prostate tumor recurrences.
Aug. 12, 2017
- Prostate cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Jan. 21, 2017.
- Wein AJ, et al., eds. Campbell-Walsh Urology. 11th ed. Philadelphia, Pa.: Elsevier; 2016. http://wwwclinicalkey.com. Accessed Feb. 21, 2017.
- Gunderson LL, et al. Prostate Cancer. In:Clinical Radiation Oncology. 4th ed. Philadelphia, Pa.: Elsevier; 2016. http://www.clincalkey.com. Accessed Feb. 20, 2017.
- What you need to know about prostate cancer. National Cancer Institute. http://www.cancer.gov/publications/patient-education/wyntk-prostate-cancer. Accessed Feb. 8, 2017.
- Niederhuber JE, et al., eds. Prostate cancer. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Jan. 21, 2017.
- Distress management. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Feb. 20, 2017.
- Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. October 24, 2016.
- Smith RA, et al. Cancer screening in the United States, 2015: A review of current American Cancer Society guidelines and current issues in cancer screening. CA: A Cancer Journal for Clinicians. 2015;65:30.
- Prostate cancer prevention (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/prevention/prostate/healthprofessional. Accessed Feb. 20, 2017.
- Castle EP (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. April 12, 2017.
- Choline C-11 injection (prescribing information). Rochester, Minn. Mayo Clinic PET Radiochemistry Facility; 2012. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2012/203155Orig1s000ltr.pdf. Accessed Feb. 22, 2017.
- Vourganti S. et al. MR/US fusion technology: What makes it tick? Current Urology Reports. 2017;18:20.
- Rong N, et al. Clinically available RNA profiling tests of prostate tumors: utility and comparison. Asian Journal of Andrology. 2016;18:575.
- Conrad CA, et al. Clinically available RNA profiling tests of prostate tumors: Utility and comparison. Asian Journal of Andrology. 2016;18:505.
- Koboldt DC, et al. Rare variation in TET2 is associated with clinically relevant prostate carcinoma in African Americans. Cancer Epidemiology, Biomarkers & Prevention. 2016;25:11.
- Gettman MT, et al. Current status of robotics in urologic laparoscopy. European Urology. 2003;43:106.
- Krambeck AE, et al. Radical prostatectomy for prostatic adenocarcinoma: a matched comparison of open retropubic and robot-assisted techniques. BJU International. 2008;103;448.
- Ashfaq A, et al. Incidence and outcomes of ventral hernia repair after robotic retropubic prostatectomy: A retrospective cohort of 570 consecutive cases. International Journal of Surgery. 2017;38:74.
- Alshalalfa1 A, et al. Low PCA3 expression is a marker of poor differentiation in localized prostate tumors: Exploratory analysis from 12,076 patients. Oncotarget. In press. Accessed April 12, 2017.
- Kaushik D, et al. Oncological outcomes following radical prostatectomy for patients with pT4 prostate cancer. International Brazilian Journal of Urology. 2016;42:1091.
- Moris L, et al. Impact of lymph node burden on survival of high-risk prostate cancer patients following radical prostatectomy and pelvic lymph node dissection. Frontiers in Surgery. 2016;3:65.
- Leibovich BC (expert opinion). Mayo Clinic, Rochester, Minn. June 2, 2017.