Mayo Clinic researchers are working to improve diagnosis and treatment of progressive supranuclear palsy. Specific efforts involve mapping changes in the brains of people with the condition, comparing familial and sporadic cases, using imaging to predict disease progression and to pinpoint diagnosis, and looking for environmental and genetic factors that may be associated with the condition.
Mayo Clinic also has one of the largest progressive supranuclear palsy brain banks in the world.
Read more about research in Mayo Clinic's Parkinson's Disease and Clinical Genetics Laboratory and in the Movement Disorders Laboratory.
See a list of publications by Mayo Clinic doctors on progressive supranuclear palsy on PubMed, a service of the National Library of Medicine.
April 10, 2014
- J. Eric Ahlskog, M.D., Ph.D.
- Charles H. Adler, M.D., Ph.D.
- Bradley F. Boeve, M.D.
- James H. Bower, M.D.
- John N. Caviness, M.D.
- Keith A. Josephs, M.D.
- Ryan J. Uitti, M.D.
- Jay A. Van Gerpen, M.D.
- Zbigniew K. Wszolek, M.D.
- Factor SA. Progressive supranuclear palsy (PSP).http://www.uptodate.com/home. Accessed Dec. 3, 2013.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed Dec. 3, 2013.
- Ropper AH, et al. Adams & Victor's Principles of Neurology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=54. Accessed Dec. 3, 2013.
- Boeve BF. Progressive supranuclear palsy. Parkinsonism and Related Disorders. 2012;18S1:S192.
- Josephs KA, et al. Modeling trajectories of regional volume loss in progressive supranuclear palsy. Movement Disorders. 2013;28:1117.
- Fujioka S, et al. Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy. Neurology. 2013;80:2076.
- Progressive supranuclear palsy fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.7.gov/disorders/psp/detail_psp.htm. Accessed Dec. 3, 2013.
- Liscic RM, et al. Differentiation of progressive supranuclear palsy: Clinical, imaging and laboratory tools. Acta Neurologica Scandinavica. 2013;127:362.
- Josephs KA, et al. A clinicopathological study of vascular progressive supranuclear palsy. Archives of Neurology. 2002;59:1597.
- Josephs KA, et al. Apraxia of speech and nonfluent aphasia: A new clinical marker for corticobasal degeneration and progressive supranuclear palsy. Current Opinion in Neurology. 2008;21:688.
- Whitwell JL, et al. Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy. European Journal of Neurology. 2013;20:629.
- Whitwell JL, et al. Imaging measures predict progression in progressive supranuclear palsy. Movement Disorders. 2012;87:1801.
- Botha H, et al. The pimple sign of progressive supranuclear palsy. Parkinsonism and Related Disorders. In press. Accessed Dec. 3, 2013.
- Coon EA, et al. Primary lateral sclerosis as progressive supranuclear palsy: Diagnosis by diffusion tensor imaging. Movement Disorders. 2012;27:903.
- Josephs KA (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 13, 2013.
- AskMayoExpert. Can rehabilitation help patients with Parkinson's disease and other movement disorders? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- A guide for people living with PSP, CBD, and other atypical Parkinsonian disorders. CurePSP. http://www.psp.org/education/. Accessed Dec. 4, 2013.