Research

Mayo Clinic researchers were among the first to describe primary sclerosing cholangitis. Other research done at Mayo has helped to refine diagnostic tests, improve treatment and assess the results of liver transplants for people with primary sclerosing cholangitis. Mayo Clinic researchers also developed mathematical models to help physicians predict long-term survival for people with primary sclerosing cholangitis.

Researchers at Mayo Clinic are currently studying the use of the fluorescence in situ hybridization (FISH) test in the diagnosis of bile duct cancer in people with primary sclerosing cholangitis. Another study is looking at genetic predisposition to primary sclerosing cholangitis.

Basic research related to primary sclerosing cholangitis and other liver diseases is conducted in the following Mayo Clinic laboratories:

Publications

See a list of publications on primary sclerosing cholangitis by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

July 07, 2017
References
  1. Lazaridis KN, et al. Primary sclerosing cholangitis. New England Journal of Medicine. 2016;375:1161.
  2. Kowdley KV. Primary sclerosing cholangitis in adults: Clinical manifestations and diagnosis. http://www.uptodate.com/home. Accessed Nov. 11, 2016.
  3. Lindor KD, et al. ACG clinical guideline: Primary sclerosing cholangitis. American Journal of Gastroenterology. 2015;110:646.
  4. Primary sclerosing cholangitis (PSC). American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/psc/. Accessed Nov. 11, 2016.
  5. Longo DL, et al. Diseases of the gallbladder and bile ducts. In: Harrison's Principles of Internal Medicine. 18th ed. New York, N.Y.: The McGraw Hill Companies; 2012. http://www.accessmedicine.com. Accessed Nov. 11, 2016.
  6. Kowdley KV. Primary sclerosing cholangitis: Epidemiology and pathogenesis. http://www.uptodate.com/home. Accessed Nov. 11, 2016.
  7. Kowdley KV. Primary sclerosing cholangitis: Management. http://www.uptodate.com/home. Accessed Nov. 11, 2016.
  8. Beuers U, et al. Pruritus in cholestasis: Facts and fiction. Hepatology. 2014;60:399.
  9. Poupon R. Pruritus associated with cholestasis. http://www.uptodate.com/home. Accessed Nov. 11, 2016.
  10. Brown A. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Nov. 3, 2016.
  11. Jopson L, et al. Understanding and treating fatigue in primary biliary cirrhosis and primary sclerosing cholangitis. Clinical Liver Disease. 2016;20:131.
  12. Primary sclerosing cholangitis (PSC). American College of Gastroenterology. http://patients.gi.org/topics/primary-sclerosing-cholangitis-psc/. Accessed Nov. 16, 2016.
  13. Liver health and wellness. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/liverhealth/. Accessed Nov. 16, 2016.
  14. Medications and the liver. American College of Gastroenterology. http://patients.gi.org/topics/medications-and-the-liver/. Accessed Nov. 16, 2016.
  15. Picco MF (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 20, 2016.