Tests and procedures used to diagnose primary sclerosing cholangitis include:
Aug. 15, 2014
- Liver function blood tests. A blood test to check your liver function, including levels of your liver enzymes, can give your doctor clues about your diagnosis.
- MRI of your bile ducts. Magnetic resonance cholangiopancreatography (koh-lan-jee-o-pan-cree-uh-TOG-ruh-fee) uses magnetic resonance imaging (MRI) to make images of your liver and bile ducts.
- X-rays of your bile ducts. You may need a type of bile duct X-ray called endoscopic retrograde cholangiopancreatography (ERCP) in addition to or instead of an MRI. To make your bile ducts visible on an X-ray, your doctor uses a flexible tube passed down your throat to inject dye into the area of your small intestine where your bile ducts empty. ERCP is the test of choice if signs and symptoms persist despite no abnormalities on MRI. ERCP is often the initial test if you're unable to have an MRI because of a metal implant in your body.
- Testing a sample of liver tissue. A liver biopsy is a procedure to remove a piece of liver tissue for laboratory testing. Your doctor inserts a needle through your skin and into your liver to extract a tissue sample. Liver biopsy can help determine the extent of damage to your liver. The test is used only when the diagnosis of primary sclerosing cholangitis is still uncertain after less invasive tests.
- Kowdley KV. Primary sclerosing cholangitis in adults: Clinical manifestations and diagnosis. http://www.uptodate.com/home. Accessed Jan. 24, 2014.
- Singh S, et al. Primary sclerosing cholangitis: Diagnosis, prognosis, and management. Clinical Gastroenterology and Hepatology. 2013;11:898.
- Eaton JE, et al. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology. 2013;45:521.
- Imam MH, et al. Pathogenesis and management of pruritus in cholestatic liver disease. Journal of Gastroenterology and Hepatology. 2012;27:1150.
- Kowdley KV. Primary sclerosing cholangitis: Epidemiology and pathogenesis. http://www.uptodate.com/home. Accessed Dec. 18, 2013.
- Hirschfield GM, et al. Primary sclerosing cholangitis. The Lancet. 2013;382:1587.
- Kowdley, KV. Primary sclerosing cholangitis in adults: Treatment. http://www.uptodate.com/home. Accessed Dec. 18, 2013.
- Bunchorntavakul C, et al. Pruritis in chronic liver disease. Clinics in Liver Disease. 2012;16:331.
- Phan NQ, et al. Antipruritic treatment with systemic µ-opioid receptor antagonists: A review. Journal of the American Academy of Dermatology. 2010;63:680.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Jan. 22, 2014.
- Carbone M, et al. Autoimmune liver disease, autoimmunity and liver transplantation. Journal of Hepatology. 2014;60:210.
- Murad SD, et al. Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers. Gastroenterology. 2012;143:88.
- Barbara Woodward Lips Patient Education Center. Perihilar and distal cholangiocarcinoma. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Primary sclerosing cholangitis. American College of Gastroenterology. http://patients.gi.org/topics/primary-sclerosing-cholangitis-psc/. Accessed Jan. 24, 2014.
- Liver health and wellness. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/liverhealth/. Accessed Jan. 24, 2014.
- Barbara Woodward Lips Patient Education Center. Nutrition for people with liver disease. Rochester, Minn.: Mayo Foundation for Medical Research; 2013.
- Medication safety. Canadian Liver Foundation. http://www.liver.ca/liver-health/liver-disease-prevention/tips-for-healthy-liver/drug-safety.aspx. Accessed Jan. 23, 2014.
- Medications and the liver. American College of Gastroenterology. http://patients.gi.org/topics/medications-and-the-liver/. Accessed Jan. 24, 2014.
- Rosenthal TC, et al. Fatigue: An overview. American Family Physician. 2008;78:1173.