Primary sclerosing (skluh-ROHS-ing) cholangitis (koh-lan-JIE-tis) is a disease of the bile ducts in your liver. The term "cholangitis" in primary sclerosing cholangitis refers to inflammation of the bile ducts, while the term "sclerosing" describes the hardening and scarring of the bile ducts that result from chronic inflammation.

Primary sclerosing cholangitis is a progressive disease that leads to liver damage and, eventually, liver failure. Liver transplant is the only known cure for primary sclerosing cholangitis, but transplant is typically reserved for people with severe liver damage.

Researchers continue looking for treatments to slow or reverse bile duct damage caused by primary sclerosing cholangitis. But until a treatment is found, doctors care for people with primary sclerosing cholangitis by reducing signs and symptoms of complications.

Aug. 01, 2014

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