Mayo Clinic has been conducting research on primary biliary cirrhosis for more than 40 years, and many treatments for the disease have been studied here. Mayo Clinic was one of the first centers to study ursodeoxycholic acid (UDCA) as a treatment option. Researchers are currently studying new medications for people with only a partial response to UDCA.
Researchers are also investigating the treatment of related diseases such as osteoporosis, the effectiveness of current medications, the effects of liver transplantation and the causes of the disease. People treated for primary biliary cirrhosis at Mayo Clinic may have the opportunity to participate clinical trials.
Mayo Clinic researchers have made numerous contributions to understanding the genetics of this disease, including helping to find several gene variations that seem to predispose people to primary biliary cirrhosis. These discoveries are the first step toward developing targeted treatments for individuals and potentially curing the disease.
Researchers at Mayo Clinic have found that first-degree relatives — parents, siblings or children — of people with primary biliary cirrhosis are more likely to have a protein that indicates presence of the disease in their blood (biomarker). This finding could allow doctors to identify the disease early in first-degree relatives with a simple blood test so that treatment can begin before the disease causes irreversible liver damage.
Basic research related to primary biliary cirrhosis and other liver diseases is conducted in the following Mayo Clinic laboratories:
See a list of publications by Mayo Clinic doctors on primary biliary cirrhosis on PubMed, a service of the National Library of Medicine.
Nov. 22, 2014
- Gregory J. Gores, M.D.
- Piet C. de Groen, M.D.
- Nicholas F. LaRusso, M.D.
- Konstantinos N. Lazaridis, M.D.
- David M. Nagorney, M.D.
- Lewis R. Roberts, M.B., Ch.B., Ph.D.
- Charles B. Rosen, M.D.
- Jayant A. Talwalkar, M.D.
- Russell H. Wiesner, M.D.
- Denise M. Harnois, D.O.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed Oct.8, 2014.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. Oct. 25, 2014.
- Primary biliary cirrhosis. The National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/primarybiliarycirrhosis/index.aspx. Accessed Oct. 8, 2014.
- Juran BD, et al. Environmental factors in primary biliary cirrhosis. Seminars in Liver Disease. 2014;34:265.
- Lindor, KD, et al. Primary biliary cirrhosis. American Association for the Study of Liver Diseases Practice Guidelines. Hepatology. 2009;50:291.
- Poupon R. Clinical manifestations, diagnosis, and natural history of primary biliary cirrhosis. http://www.uptodate.com/home. Accessed Oct. 8, 2014.
- Boyer TD, et al., eds. Zakim & Boyer's Hepatology: A Textbook of Liver Disease. 6th ed. https://www.clinicalkey.com. Accessed Oct. 8, 2014.
- Poupon R. Overview of the treatment of primary biliary cirrhosis. http://www.uptodate.com/home. Accessed Oct. 8, 2014.
- Flamm S, et al. Liver transplantation in primary biliary cirrhosis. http://www.uptodate.com/home. Accessed Oct. 8, 2014.
- Honda A, et al. Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. Hepatology. 2013;57:1931.
- AskMayoExpert. What is magnetic resonance elastography (MRE) and what are the indications for an MRE examination? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Singal AK, et al. Model for end-stage liver disease. Journal of Clinical and Experimental Hepatology. 2013;3:50.
- PCBers. http://pbcers.org/. Accessed Oct. 8, 2014.
- Mells GF, et al. Impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study. Hepatology. 2013;58:273.
- American Liver Foundation. http://www.liverfoundation.org/support/. Accessed Oct. 21, 2014.
- Venkatesh SK, et al. Magnetic resonance elastography of liver: Clinical applications. Journal of Computer Assisted Tomography. 2013;37:887.
- Imam MH, et al. Pathogenesis and management of pruritus in cholestatic liver disease. Journal of Gastroenterology and Hepatology. 2012;27:1150.
- Bunchorntavakul C, et al. Pruritis in chronic liver disease. Clinics in Liver Disease. 2012;16:331.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. Oct. 6, 2014.
- Martin P, et al. Evaluation for liver transplantation in adults: 2013 Practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology. 2014;59:1144.