Although some people with primary biliary cirrhosis remain symptom-free for years after they're diagnosed, others experience a number of signs and symptoms.

Common early symptoms include:

  • Fatigue
  • Itchy skin
  • Dry eyes and mouth

Later signs and symptoms may include:

  • Pain in the upper right portion of the abdomen
  • Bone, muscle or joint (musculoskeletal) pain
  • Yellowing of the skin and eyes (jaundice)
  • Darkening of the skin that's not related to sun exposure (hyperpigmentation)
  • Swollen feet and ankles (edema)
  • Buildup of fluid in the abdomen due to liver failure (ascites)
  • Fatty deposits on the skin around your eyes, your eyelids, or in the creases in your palms, soles, elbows or knees (xanthomas)
  • Weak and brittle bones (osteoporosis), which can lead to fractures
  • Elevated cholesterol
  • Diarrhea that can be greasy (steatorrhea)
  • Underactive thyroid (hypothyroidism)
Nov. 22, 2014

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