Treatment at Mayo Clinic

By Mayo Clinic Staff


Mayo Clinic accepts appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System sites.

Request an Appointment

Treatment generally focuses on managing the underlying plasma cell disorder. At Mayo Clinic, a multispecialty team of doctors works together to develop a personalized treatment plan for you based on your needs.

The treatment options include:

  • Radiation therapy to destroy plasma cells in abnormal bone, if you don't have widespread lesions in your bone marrow.
  • Chemotherapy to destroy abnormal cells, if bone marrow lesions are widespread.
  • Peripheral blood stem cell transplant, in which your own stem cells are collected from your blood and stored for a short time while you receive high-dose chemotherapy. The stem cells are then returned to your body via a vein.

Treatment often results in symptom relief. The extent of relief depends on the severity of the symptoms before treatment.

Other ways to manage your symptoms include:

  • Anti-inflammatory medications, to subdue your body's immune response and to help produce extra bone marrow cells
  • Pain medications
  • Hormone replacement therapy, if you're experiencing hormonal abnormalities
  • Physical therapy to strengthen limbs weakened by neuropathy
  • Braces or walking aids, if you experience disability from neuropathy

People with POEMS syndrome need lifelong care because relapse is possible. At Mayo Clinic, follow-up exams are scheduled every three months.

July 17, 2014