Treatment at Mayo Clinic

By Mayo Clinic Staff

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Treatment generally focuses on managing the underlying plasma cell disorder. At Mayo Clinic, a multispecialty team of doctors works together to develop a personalized treatment plan for you based on your needs.

The treatment options include:

  • Radiation therapy to destroy plasma cells in abnormal bone, if you don't have widespread lesions in your bone marrow.
  • Chemotherapy to destroy abnormal cells, if bone marrow lesions are widespread.
  • Peripheral blood stem cell transplant, in which your own stem cells are collected from your blood and stored for a short time while you receive high-dose chemotherapy. The stem cells are then returned to your body via a vein.

Treatment often results in symptom relief. The extent of relief depends on the severity of the symptoms before treatment.

Other ways to manage your symptoms include:

  • Anti-inflammatory medications, to subdue your body's immune response and to help produce extra bone marrow cells
  • Pain medications
  • Hormone replacement therapy, if you're experiencing hormonal abnormalities
  • Physical therapy to strengthen limbs weakened by neuropathy
  • Braces or walking aids, if you experience disability from neuropathy

People with POEMS syndrome need lifelong care because relapse is possible. At Mayo Clinic, follow-up exams are scheduled every three months.

Jul. 17, 2014

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