Treatment generally focuses on managing the underlying plasma cell disorder. At Mayo Clinic, a multispecialty team of doctors works together to develop a personalized treatment plan for you based on your needs.
The treatment options include:
- Radiation therapy to destroy plasma cells in abnormal bone, if you don't have widespread lesions in your bone marrow.
- Chemotherapy to destroy abnormal cells, if bone marrow lesions are widespread.
- Peripheral blood stem cell transplant, in which your own stem cells are collected from your blood and stored for a short time while you receive high-dose chemotherapy. The stem cells are then returned to your body via a vein.
Treatment often results in symptom relief. The extent of relief depends on the severity of the symptoms before treatment.
Other ways to manage your symptoms include:
- Anti-inflammatory medications, to subdue your body's immune response and to help produce extra bone marrow cells
- Pain medications
- Hormone replacement therapy, if you're experiencing hormonal abnormalities
- Physical therapy to strengthen limbs weakened by neuropathy
- Braces or walking aids, if you experience disability from neuropathy
People with POEMS syndrome need lifelong care because relapse is possible. At Mayo Clinic, follow-up exams are scheduled every three months.
July 17, 2014
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- Daroff RB, et al. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, Pa.: Elsevier Saunders; 2012. https://www.clinicalkey.com. Accessed April 29, 2014.
- Barbara Woodward Lips Patient Education Center. POEMS syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Dispenzieri A. POEMS syndrome: 2014 update on diagnosis, risk-stratification and management. American Journal of Hematology. 2014;89:213.
- Rajkumar SV. POEMS syndrome. http://www.uptodate.com/home. Accessed April 29, 2014.
- POEMS syndrome. Genetic and Rare Diseases Information Center. http://rarediseases.info.nih.gov/gard/7411/poems-syndrome/resources/1. Accessed April 29, 2014.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. May 12, 2014.
- D'Souza A, et al. Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): A single-center experience. Blood. 2012;120:56.
- Humeniuk MS, et al. Outcomes of patients with POEMS syndrome treated initially with radiation. Blood. 2013;122:68.
- Dispenzieri A. How I treat POEMS syndrome. Blood. 2012;119:5650.
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