People with rare inherited disorders have an increased risk of developing a pheochromocytoma or paraganglioma, and tumors associated with these disorders are more likely to be cancerous. These genetic conditions include the following:
May. 02, 2014
- Multiple endocrine neoplasia, type II (MEN II) is a disorder resulting in tumors in more than one part of the body's hormone-producing (endocrine) system. The locations of other tumors associated with MEN II include the thyroid, parathyroid, lips, tongue and gastrointestinal tract.
- Von Hippel-Lindau disease can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys.
- Neurofibromatosis 1 (NF1) results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve.
- Hereditary paraganglioma syndromes are inherited disorders that result in either pheochromocytomas or paragangliomas.
- Pheochromocytoma. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/adrenal_disorders/pheochromocytoma.html?qt=pheochromocytoma&alt=sh. Accessed Dec. 4, 2013.
- Pheochromocytoma and paraganglioma treatment (PDQ®): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/pheochromocytoma/HealthProfessional. Accessed Dec. 3, 2013.
- Chen H, et al. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010;39:775.
- Young WF, Jr. Paragangliomas: Clinical overview. Annals of the New York Academy of Sciences 2006;1073:21.
- Avoid food-drug interactions: A guide from the National Consumers League and U.S. Food and Drug Administration. National Consumers League and U.S. Food and Drug Administration. http://www.fda.gov/downloads/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/EnsuringSafeUseofMedicine/GeneralUseofMedicine/UCM229033.pdf. Accessed Dec. 5, 2013.
- Grossman E, et al. Drug-induced hypertension: An unappreciated cause of secondary hypertension. The American Journal of Medicine 2012;125:14.
- Joynt KE, et al. Paragangliomas: Etiology, presentation, and management. Cardiology in Review 2009;17:159.
- Multiple endocrine neoplasia type II. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1257. Accessed Dec. 11, 2013.
- Von Hippel-Landau disease. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1463. Accessed Dec. 11, 2013.
- Neurofibromatosis 1. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1109. Accessed Dec. 11, 2013.
- Hereditary paraganglioma-pheochromocytoma syndromes. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1548. Accessed Dec. 11, 2013.
- Overview of hypertension. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/cardiovascular_disorders/hypertension/overview_of_hypertension.html. Accessed Dec. 4, 2013.
- Jimenez C, et al. Current and future treatments for malignant pheochromocytoma and sympathetic paraganglioma. Current Oncology Reports 2013;15:356.
- High blood pressure—Medicines to help you. U.S. Food and Drug Administration. http://www.fda.gov/forconsumers/byaudience/forwomen/ucm118594.htm. Accessed Dec. 10, 2013.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 19, 2013.
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