Researchers don't know exactly what causes the development of a pheochromocytoma. They do understand that the tumor develops in specialized cells, called chromaffin cells, located in the center of an adrenal gland. These cells produce and release certain hormones, primarily adrenaline (epinephrine) and noradrenaline (norepinephrine).
The role of hormones
Adrenaline and noradrenaline are hormones that normally function as the trigger for your body's fight-or-flight response to a perceived threat. The hormones prompt higher blood pressure, a faster heart rate and a boost in other body systems that enable you to react quickly with a burst of energy. A pheochromocytoma results in the irregular and excessive release of these hormones.
While most chromaffin cells reside in the adrenal glands, small clusters of these cells are also located in the heart, head, neck, bladder, back wall of the abdomen and along the spine. Tumors in these chromaffin cells, called paragangliomas, may result in the same effects on the body.
May. 02, 2014
- Pheochromocytoma. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/adrenal_disorders/pheochromocytoma.html?qt=pheochromocytoma&alt=sh. Accessed Dec. 4, 2013.
- Pheochromocytoma and paraganglioma treatment (PDQ®): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/pheochromocytoma/HealthProfessional. Accessed Dec. 3, 2013.
- Chen H, et al. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010;39:775.
- Young WF, Jr. Paragangliomas: Clinical overview. Annals of the New York Academy of Sciences 2006;1073:21.
- Avoid food-drug interactions: A guide from the National Consumers League and U.S. Food and Drug Administration. National Consumers League and U.S. Food and Drug Administration. http://www.fda.gov/downloads/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/EnsuringSafeUseofMedicine/GeneralUseofMedicine/UCM229033.pdf. Accessed Dec. 5, 2013.
- Grossman E, et al. Drug-induced hypertension: An unappreciated cause of secondary hypertension. The American Journal of Medicine 2012;125:14.
- Joynt KE, et al. Paragangliomas: Etiology, presentation, and management. Cardiology in Review 2009;17:159.
- Multiple endocrine neoplasia type II. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1257. Accessed Dec. 11, 2013.
- Von Hippel-Landau disease. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1463. Accessed Dec. 11, 2013.
- Neurofibromatosis 1. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1109. Accessed Dec. 11, 2013.
- Hereditary paraganglioma-pheochromocytoma syndromes. National Center for Biotechnology Medicine. http://www.ncbi.nlm.nih.gov/books/NBK1548. Accessed Dec. 11, 2013.
- Overview of hypertension. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/cardiovascular_disorders/hypertension/overview_of_hypertension.html. Accessed Dec. 4, 2013.
- Jimenez C, et al. Current and future treatments for malignant pheochromocytoma and sympathetic paraganglioma. Current Oncology Reports 2013;15:356.
- High blood pressure—Medicines to help you. U.S. Food and Drug Administration. http://www.fda.gov/forconsumers/byaudience/forwomen/ucm118594.htm. Accessed Dec. 10, 2013.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 19, 2013.
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