Print OverviewA peripheral nerve injury happens when one of the nerves located outside the brain or spinal cord is damaged. These nerves connect the brain and spinal cord to the rest of the body. They carry messages that control movement and allow the body to feel things such as temperature, pain or touch. Peripheral nerves are made of fibers called axons. These fibers are protected by surrounding tissues. Peripheral nerves are fragile, and they damage easily. A nerve injury can make it hard for the brain to communicate with muscles and organs. Damage to the peripheral nerves is called peripheral neuropathy. It's important to get medical care for a peripheral nerve injury as soon as possible. Early diagnosis and treatment may prevent complications and lasting damage.Products & ServicesA Book: Mayo Clinic Family Health BookNewsletter: Mayo Clinic Health Letter — Digital EditionShow more products from Mayo Clinic SymptomsWith a peripheral nerve injury, signs and symptoms may range from mild to serious. Your daily activities may be limited. Symptoms often depend on which nerve fibers are damaged: Motor nerves. These nerves control all the muscles under your conscious control. They include muscles for walking, talking and holding objects. Damage to these nerves can cause muscle weakness, painful cramps and muscle twitching. Sensory nerves. Because these nerves relay information about touch, temperature and pain, you may have many different symptoms. These may include numbness or tingling in the hands or feet. You may have trouble walking, keeping your balance with your eyes closed, fastening buttons, or sensing pain or changes in temperature. Injury of sensory nerves also may cause pain. Autonomic (aw-tuh-NOM-ik) nerves. This group of nerves controls activities that are not controlled consciously. For instance, these nerves control breathing, heart and thyroid function, and digestion. Symptoms may include heavy sweating, changes in blood pressure, gastrointestinal issues and not being able to handle heat. Damage to the autonomic nerves is called autonomic neuropathy. Many peripheral nerve injuries affect more than one type of nerve fiber, so you may have a range of symptoms. When to see a doctorIf you have weakness, tingling, numbness or a total loss of feeling, see a healthcare professional to find out the cause. It's important to treat peripheral nerve injuries early. Request an appointment CausesDamage to peripheral nerves can happen in different ways: An accident, a fall or sports can stretch, compress, crush or cut nerves. Certain medical conditions can damage nerves, such as diabetes, Guillain-Barre syndrome and carpal tunnel syndrome. Autoimmune diseases also can damage nerves, including lupus, rheumatoid arthritis and Sjogren syndrome. Other causes include narrowing of the arteries, changes in hormone balance and tumors. Risk factorsPeople who have physical trauma or play sports may be at higher risk of an injury that stretches or crushes peripheral nerves. People with certain medical conditions also may be at higher risk of peripheral nerve injuries. These conditions, especially diabetes, may raise the risk of nerves being compressed. By Mayo Clinic Staff Peripheral nerve injuries care at Mayo Clinic Request an appointment Diagnosis & treatment July 17, 2026 PrintShow references Peripheral neuropathy. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/peripheral-neuropathy. Accessed Sept. 13, 2025. Nerve injuries in the hand and fingers. American Academy of Orthopaedic Surgeons. https://orthoinfo.aaos.org/topic.cfm?topic=A00016. Accessed Sept. 13, 2025. Rutkove SB. Overview of upper extremity peripheral nerve syndromes. https://www.uptodate.com/contents/search. Accessed Sept. 13, 2025. Rutkove SB. Overview of lower extremity peripheral nerve syndromes. https://www.uptodate.com/contents/search. Accessed Sept. 13, 2025. Cervical radiculopathy (pinched nerve). American Academy of Orthopaedic Surgeons. https://orthoinfo.aaos.org/en/diseases--conditions/cervical-radiculopathy-pinched-nerve/. Accessed Sept. 13, 2025. Naum R, et al. Autoimmune polyneuropathies. Handbook of Clinical Neurology. 2023; doi:10.1016/B978-0-323-98818-6.00004-2. Jankovic J, et al., eds. Trauma of the nervous system: Peripheral nerve trauma. In: Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Sept. 13, 2025. Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/neurological-diagnostic-tests-and-procedures Accessed Sept. 13, 2025. Neligan PC, et al., eds. Repair and grafting of peripheral nerve. In: Plastic Surgery. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Oct. 21, 2025. Pain. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/pain. Accessed Sept. 13, 2025. Brachial plexus injuries. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/brachial-plexus-injury. Accessed Sept. 13, 2025. Strommen JA, et al. Neurophysiology during peripheral nerve surgery. Handbook of Clinical Neurology. 2022; doi:10.1016/B978-0-12-819826-1.00022-3. Ami TR. Allscripts EPSi. Mayo Clinic. Nov. 14, 2023. Related Peripheral nerve graft Peripheral nerve transfer Associated Procedures Neurological examinations Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Peripheral nerve injuriesSymptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book CON-20251929 Diseases & Conditions Peripheral nerve injuries