Factors that increase your risk of developing peripheral artery disease include:
- Obesity (a body mass index over 30)
- High blood pressure (140/90 millimeters of mercury or higher)
- High cholesterol (total blood cholesterol over 240 milligrams per deciliter, or 6.2 millimoles per liter)
- Increasing age, especially after reaching 50 years of age
- A family history of peripheral artery disease, heart disease or stroke
- High levels of homocysteine, a protein component that helps build and maintain tissue
People who smoke or have diabetes have the greatest risk of developing peripheral artery disease due to reduced blood flow.
June 22, 2012
- Peripheral artery disease. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec07/ch080/ch080f.html. Accessed May 8, 2012.
- Peripheral artery disease. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/pad/. Accessed May 8, 2012.
- Mohler III ER. Clinical features, diagnosis, and natural history of lower extremity peripheral arterial disease. http://www.uptodate.com/index. Accessed May 8, 2012.
- Prevention and treatment of PAD. American Heart Association. http://www.heart.org/HEARTORG/Conditions/More/PeripheralArteryDisease/Prevention-and-Treatment-of-PAD_UCM_301308_Article.jsp. Accessed May 8, 2012.
- Hirsch AT, et al. ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease. Journal of the American College of Cardiology. 2006;47:e1.
- Rooke TW, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral arterial disease. Circulation. 2011;124:2020.
- Kuller LH. Does ginkgo biloba reduce the risk of cardiovascular events? Circulation: Cardiovascular Quality and Outcomes. 2010;3:41.