Paraneoplastic syndromes of the nervous system are a group of rare disorders that develop in some people who have cancer. Paraneoplastic syndromes of the nervous system are the most commonly reported paraneoplastic syndromes, but these syndromes can also affect other organ systems including hormone (endocrine), skin (dermatologic), blood (hematologic) and joints (rheumatologic).
Paraneoplastic events may also in part explain some of the most common symptoms of cancer, such as fatigue, loss of appetite for food (anorexia) and weight loss.
Paraneoplastic syndromes of the nervous system occur when cancer-fighting agents of the immune system also attack parts of the brain, spinal cord, peripheral nerves or muscle. Cancers commonly associated with these disorders include lung, breast and ovarian, as well as cancers of the blood. In most cases, paraneoplastic syndromes of the nervous system occur before a cancer is diagnosed.
Depending on the component of the nervous system affected, paraneoplastic syndromes can cause problems with muscle movement or coordination, sensory perception, memory or thinking skills, or even sleep.
Sometimes the injury to the nervous system is reversible with therapy directed toward the cancer and the immune system. However, these diseases can also rapidly result in severe damage to the nervous system which can't be reversed. Regardless, treatment of the underlying cancer and other interventions may prevent further damage, improve symptoms and give you a better quality of life.
April 30, 2014
- NINDS paraneoplastic syndrome information page. National Institutes of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/paraneoplastic/paraneoplastic.htm. Accessed Dec. 18, 2013.
- Niederhuber JE, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Dec. 15, 2013.
- Pelosof LC, et al. Paraneoplastic syndromes: An approach to diagnosis and treatment. Mayo Clinic Proceedings. 2010;85:838.
- Giometto B, et al. Treatment for paraneoplastic neuropathies (Review). Cochrane Database of Systematic Reviews. http://ovidsp.tx.ovid.com/sp-3.10.0b/ovidweb.cgi?&S=BOJHFPHGIFDDNBEPNCNKNAIBLMNOAA00&Link+Set=S.sh.18%7c1%7csl_50. Accessed Dec. 18, 2013.
- Titulaer MJ, et al. Screening for tumours in paraneoplastic syndromes: Report of an EFNS Task Force. European Journal of Neurology. 2011;18:19.
- Graus F, et al. Paraneoplastic neurological syndromes. Current Opinion in Neurology. 2012;25:795.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014.
https://www.clinicalkey.com. Accessed Dec. 15, 2013.
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Dec. 15, 2013.
- Daroff RB, et al. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed Dec. 15, 2013.
- van Sonderen A, et al. Paraneoplastic syndromes of the neuromuscular junction: Therapeutic options in myasthenia gravis, Lambert-Eaton myasthenic syndrome, and neuromyotonia. Current Treatment Options in Neurology. 2013;15:224.
- Tarin D. Update on clinical and mechanistic aspects of paraneoplastic syndromes. Cancer Metastasis Review. 2013;32:707.
- Schramm N, et al. Detection of underlying malignancy in patients with paraneoplastic neurological syndromes: Comparison of 18F-FDG PET/CT and contrast-enhanced CT. European Journal of Nuclear Medicine and Molecular Imaging. 2013;40:1014.
- NINDS dysautonomia information page. National Institutes of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/dysautonomia/dysautonomia.htm. Accessed Jan. 22, 2014.
- NINDS Isaac's syndrome information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/Isaacs_syndrome/Isaacs_syndrome.htm. Accessed Dec. 18, 2013.
- Dalmau J, et al. Overview of paraneoplastic syndromes of the nervous system. http://www.uptodate.com/home. Accessed Dec.18, 2013.
- Pittock SJ (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 14, 2010.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/neurology-and-neurosurgery. Accessed Dec. 30, 2013.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/pediatric-rankings/neurology-and-neurosurgery. Accessed Dec. 30, 2013.
- Lachance DH (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 15, 2014.
- Eisen A. Disorders affecting the spinal cord. http://www.uptodate.com/home. Accessed Jan. 23, 2014.
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