To decrease your chances of developing ovarian hyperstimulation syndrome, you'll need an individualized plan for your fertility medications. Expect your doctor to carefully monitor each treatment cycle, including frequent ultrasounds to check the development of follicles and blood tests to check your hormone levels.
Strategies to help prevent OHSS include:
Feb. 14, 2014
- Adjusting medication dosage. Your doctor uses the lowest possible dose of gonadotropins to achieve the goals of stimulating your ovaries and triggering ovulation.
- Coasting. If your estrogen level is high or you have a large number of developed follicles, your doctor may have you stop injectable medications and wait a few days before giving HCG, which triggers ovulation. This is known as "coasting."
- Avoiding use of an HCG "trigger" shot. Because OHSS often develops after an HCG "trigger" shot is given, alternatives to HCG for triggering ovulation are being studied as a way to prevent OHSS.
- Freezing embryos. If you're undergoing in vitro fertilization (IVF), all the follicles (mature and immature) may be removed from your ovaries to reduce the chance of OHSS. Mature follicles are fertilized and frozen, and your ovaries are allowed to rest for one or two cycles. You can resume the IVF process at a later date, when your body is ready.
- Gera PS, et al. Ovarian hyperstimulation syndrome: Steps to maximize success and minimize effect for assisted reproductive outcome. Fertility and Sterility. 2010;94:173.
- Insler V, et al. Pathogenesis of ovarian hyperstimulation syndrome. http://www.uptodate.com/home Accessed Sept. 23, 2013.
- Shaw RW, et al. Gynaecology. 4th ed. Edinburgh, U.K.: Churchill Livingstone; 2011. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Vloeberghs V, et al. Ovarian hyperstimulation syndrome and complications of ART. Best Practice & Research Clinical Obstetrics and Gynaecology. 2009;23:691.
- Insler V, et al. Classification and treatment of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Sept. 23, 2013.
- Lentz GM, et al. Comprehensive Gynecology. 6th ed. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Luke B, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Fertility and Sterility. 2010;94:1399.
- Adams JG. Emergency Medicine: Clinical Essentials. 2nd ed. Philadelphia, Pa. Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Insler V, et al. Prevention of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Sept. 23, 2013.
- Practice Committee of the American Society for Reproductive Medicine. Ovarian hyperstimulation syndrome. Fertility and Sterility. 2006;86:S178.
- Coddington CC (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 2, 2013.
- Rollene NL, et al. Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: A case series. Fertility and Sterility. 2009;92:1169.e15.
You Are ... The Campaign for Mayo Clinic
Mayo Clinic is a not-for-profit organization. Make a difference today.