Tests and diagnosisBy Mayo Clinic Staff
Your doctor may feel the area around the affected bone for any tenderness, swelling or warmth. If you have a foot ulcer, your doctor may use a dull probe to determine the proximity of the underlying bone.
Your doctor may order a combination of tests and procedures to diagnose osteomyelitis and to determine which germ is causing the infection, such as:
Blood tests may reveal elevated levels of white blood cells and other factors that may indicate that your body is fighting an infection. If your osteomyelitis was caused by an infection in the blood, tests may reveal what germs are to blame.
No blood test exists that tells your doctor whether you do or do not have osteomyelitis. However, blood tests do give clues that your doctor uses to decide what further tests and procedures you may need.
- X-rays. X-rays can reveal damage to your bone. However, damage may not be visible until osteomyelitis has been present for several weeks. More-detailed imaging tests may be necessary if your osteomyelitis has developed more recently.
- Computerized tomography (CT) scan. A CT scan combines X-ray images taken from many different angles, creating detailed cross-sectional views of a person's internal structures.
- Magnetic resonance imaging (MRI). Using radio waves and a strong magnetic field, MRI scans can produce exceptionally detailed images of bones and the soft tissues that surround them.
A bone biopsy is the gold standard for diagnosing osteomyelitis, because it can also reveal what particular type of germ has infected your bone. Knowing the type of germ allows your doctor to choose an antibiotic that works particularly well for that type of infection.
An open biopsy requires anesthesia and surgery to access the bone. In some situations, a surgeon inserts a long needle through your skin and into your bone to take a biopsy. This procedure requires local anesthetics to numb the area where the needle is inserted. X-ray or other imaging scans may be used for guidance.
Sept. 25, 2015
- Ferri FF. Osteomyelitis. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Sept. 11, 2015.
- Marcdante KJ, et al. Osteomyelitis. In: Nelson Essentials of Pediatrics. 7th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. https://www.clinicalkey.com. Accessed Sept. 11, 2015.
- Osteomyelitis. Merck Manual Professional Version. http://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/infections-of-joints-and-bones/osteomyelitis. Accessed Sept. 11, 2015.
- Kremers HM, et al. Trends in the epidemiology of osteomyelitis: A population-based study, 1969 to 2009. The Journal of Bone and Joint Surgery. 2015;97:837.
- Lalani T. Overview of osteomyelitis. https://www.uptodate.com/home. Accessed Sept. 13, 2015.
- Marx JA, et al., eds. Bone and joint infections. In: Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2014. http://www.clinicalkey.com. Accessed Sept. 13, 2015.
- Radcliffe G, Osteomyelitis: A historical and basic sciences review. Orthopaedics and Trauma. In press. Accessed Sept. 13, 2015.