In-depth

Symptoms

Fatigue

Shortness of breath

Tests and diagnosis

Bone marrow biopsy

Complete blood count (CBC)

Genetic testing

Genetic testing is used to detect altered genes that may cause illness or disease. Although genetic testing can offer important health information, it has limitations.

MRI

Ultrasound

Treatments and drugs

Blood transfusion

Bone marrow transplant

Chemotherapy

Radiation therapy

Splenectomy

Nov. 02, 2016
References
  1. AskMayoExpert. Primary myelofibrosis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
  2. Kaushansky K, et al., eds. Primary myelofibrosis. In: Williams Hematology. 9th ed. New York, N.Y.: McGraw-Hill Education; 2016. http://www.accessmedicine.com. Accessed Sept. 22, 2016.
  3. Hoffman R, et al. Primary myelofibrosis. In: Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed Sept. 22, 2016.
  4. Tefferi A. Myeloproliferative neoplasms: A decade of discoveries and treatment advances. American Journal of Hematology. 2016;91:50.
  5. Thorium. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=659&tid=121. Accessed Sept. 22, 2016.
  6. Jakafi (prescribing information). Wilmington, Del.: Incyte Corp.; 2016. http://www.jakafi.com. Accessed Sept. 22, 2016.
  7. Blood-forming stem cell transplants. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. Accessed Sept. 22, 2016.
  8. Mesa RA. The evolving treatment paradigm in myelofibrosis. Leukemia & Lymphoma. 2013;2:242.
  9. Tefferi A, et al. One thousand patients with primary myelofibrosis: The Mayo Clinic experience. Mayo Clinic Proceedings. 2012;87:25.
  10. Palliative care. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Sept. 22, 2016.
  11. Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 19, 2016.