Although the cause of myelofibrosis often isn't known, certain factors are known to increase your risk:
Aug. 01, 2014
- Age. Myelofibrosis can affect anyone, but it's most often diagnosed in people in their 50s and 60s.
- Another blood cell disorder. A small portion of people with myelofibrosis develop the condition as a complication of essential thrombocythemia or polycythemia vera.
- Exposure to certain chemicals. Myelofibrosis has been linked to exposure to industrial chemicals such as toluene and benzene.
- Exposure to radiation. People exposed to high levels of radiation, such as survivors of atomic bomb attacks, have an increased risk of myelofibrosis. Some people who received a radioactive contrast material called Thorotrast, used from the 1920s to the 1950s, have developed myelofibrosis.
- Hoffman R, et al. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2013. http://www.clinicalkey.com. Accessed Sept. 23, 2013.
- Mesa RA. The evolving treatment paradigm in myelofibrosis. Leukemia & Lymphoma. 2013;2:242.
- Tefferi A, et al. One thousand patients with primary myelofibrosis: The Mayo Clinic experience. Mayo Clinic Proceedings. 2012;87:25.
- Myelofibrosis facts. Leukemia & Lymphoma Society. http://www.lls.org/#/diseaseinformation/myeloproliferativediseases/idiopathicmyelofibrosis. Accessed Sept. 23, 2013.
- Thorium. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=659&tid=121. Accessed Sept. 23, 2013.
- Jakafi (prescribing information). Wilmington, Del.: Incyte Corporation; 2013. http://www.jakafi.com. Accessed Sept. 23, 2013.
- Bone marrow transplantation and peripheral blood stem cell transplantation. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Therapy/bone-marrow-transplant. Accessed Sept. 25, 2013.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. July 5, 2013.
- Mesa RA (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. Sept. 26, 2013.