Below are current clinical trials.8 studies in Mild cognitive impairment (MCI)
(open studies only).
Filter this list of studies by location, status and more.
This study is being done to learn more about possible ways in which the brain might stop working properly before the first signs of Alzheimer’s disease. In addition, it is hoped that the methods used to study and identify brain abnormalities before memory loss begins, will help to identify people who might benefit most from preventive therapy. It is also hoped that it will create a faster way to study new preventative treatments when they become available to test.
This study is being done to learn more about normal memory and aging, mild memory and thinking problems, Alzheimer's disease and other forms of dementia. This study will help us determine how often memory problems occur in people in our community, and help to identify factors that may influence changes in memory and thinking skills.
The goal of this study is to gain a better understanding of the status of advanced care planning among caregivers of patients with dementia and examine how this differs by race and disease stage.
The goal of this study is to establish and maintain a neurology disease biospecimen bank containing samples of blood and/or cerebral spinal fluid from patients with symptoms of cognitive decline as well as patients with symptoms of Parkinson’s disease.
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.
All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Jacksonville, Fla., Rochester, Minn.
This study is being done to learn more about normal memory and aging, mild memory and thinking problems, Alzheimer's disease and other forms of dementia.
The overall aims of this renewal application are to prove that magnetic resonance imaging and magnetic resonance spectroscopy (MRI/MRS) measurements can predict development of Alzheimer’s Disease (AD), and that serial MRI/MRS measurements are valid biomarkers of AD disease progression. Study of three clearly distinguishable clinical groups: 1) cognitively normal subjects, 2) patients with probable dementia and 3) patients with a mild cognitive impairment (MCI). Patients and normals will be drawn from the Alzheimer’s Disease Research Center (AG16574), other dementia related studies in our program and Mayo neurodegenerative disease clinics.
Jacksonville, Fla., Rochester, Minn.
To further investigate biomarkers in CSF as possible predictors for mild cognitive impairment and dementia
Aug. 17, 2017
- McDade EM, et al. Mild cognitive impairment: Epidemiology, pathology, and clinical assessment. http://www.uptodate.com/home. Accessed April 8, 2016.
- Daroff RB, et al. Alzheimer disease and other dementias. In: Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed April 8, 2016.
- Knopman DS, et al. Mild cognitive impairment and mild dementia: A clinical perspective. Mayo Clinic Proceedings. 2014;89:1452.
- Albert MS, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia. 2011;7:270.
- Mild cognitive impairment (MCI). Alzheimer's Association. http://www.alz.org/dementia/mild-cognitive-impairment-mci.asp. Accessed April 8, 2016.
- Penna S. Cognitive and emotional dysfunction in mild cognitive impairment. Clinics in Geriatric Medicine. 2013;29:773.
- McDade EM, et al. Mild cognitive impairment: Prognosis and treatment. http://www.uptodate.com/home. Accessed April 8, 2016.
- Ferri FF. Mild cognitive impairment (MCI). In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed April 8, 2016.
- Reinjders J, et al. Cognitive interventions in healthy older adults and people with mild cognitive impairment: A systematic review. Ageing Research Reviews. 2013;12:263.
- Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Jan. 19, 2016.
- Graff-Radford N (expert opinion). Mayo Clinic, Rochester, Minn. April 20, 2016.
Mild cognitive impairment (MCI)