Risk factors for microscopic colitis include:
- Age and gender. Microscopic colitis is most common in people ages 50 to 70 and more common in women than men.
- Immune system problems. People with microscopic colitis sometimes also have an autoimmune disorder, such as celiac disease, thyroid disease or rheumatoid arthritis.
- Smoking. Recent research studies have shown an association between tobacco smoking and microscopic colitis, especially in people ages 16 to 44.
Some research studies indicate that using certain medications may increase your risk of microscopic colitis. But not all studies agree. Medications linked to the condition include:
- Aspirin, acetaminophen (Tylenol, others), and ibuprofen (Advil, Motrin IB, others)
- Proton pump inhibitors, including lansoprazole
- Acarbose (Precose)
- Ranitidine (Zantac)
- Selective serotonin reuptake inhibitors, such as sertraline (Zoloft)
It's not clear why some people who use these medications develop microscopic colitis while others don't.
Jan. 30, 2013
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed Nov. 4, 2012.
- Collagenous colitis and lymphocytic colitis. National Institute for Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/collagenouscolitis/index.aspx. Accessed Nov. 4, 2012.
- AskMayoExpert. Are lymphocytic and collagenous colitis treated similarly? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Pardi DS, et al. Microscopic colitis. Reviews in Basic and Clinical Gastroenterology and Hepatology. 2011;140:1155.
- AskMayoExpert. Does surgery have a role in management of microscopic colitis? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Chetty R, et al. Lymphocytic and collagenous colitis: An overview of so-called microscopic colitis. Nature Reviews Gastroenterology and Hepatology. 2012; 9:209.
- AskMayoExpert. Should all patients with microscopic colitis be tested for celiac disease? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Nutrition therapy for diarrhea. Nutrition Care Manual. American Dietetic Association. https://docs.google.com/viewer?a=v&q=cache:kL8NLFTBEt8J:nutritioncaremanual.org/vault/editor/Docs/DiarrheaNutritionTherapy_FINAL.pdf+nutrition+therapy+for+diarrhea&hl=en&gl=us&pid=bl&srcid=ADGEEShCAF64UkfWELX-_iienWkqA6SM2sk2HKe8HmEr5fOT-ZLzW9hbdwSoOuVhxjn4IykLy1popBOTKYxVT2hrPhqImrzpW_kzIhxffQ5ZNDkMp_lwP13vX8Xl1FmjaWJ5QDNzHQBg&sig=AHIEtbQw86uZbSC8HTTPMg8rQFWkFBHbPA. Accessed Nov.4, 2012.