Microscopic colitis is an inflammation of the large intestine (colon) that causes persistent watery diarrhea. The disorder gets its name from the fact that it's necessary to examine colon tissue under a microscope to identify it.
There are two types of microscopic colitis:
- Collagenous colitis, in which a thick layer of protein (collagen) develops in colon tissue
- Lymphocytic colitis, in which white blood cells (lymphocytes) increase in colon tissue
It isn't known whether collagenous (kuh-LAYJ-uh-nus) colitis and lymphocytic colitis are two separate disorders or represent different phases of the same condition. However, symptoms of collagenous colitis and lymphocytic colitis are similar, as are testing and treatment.
The symptoms of microscopic colitis can come and go frequently. Sometimes the symptoms resolve on their own. If not, your doctor can suggest a number of effective medications.
Jan. 30, 2013
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed Nov. 4, 2012.
- Collagenous colitis and lymphocytic colitis. National Institute for Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/collagenouscolitis/index.aspx. Accessed Nov. 4, 2012.
- AskMayoExpert. Are lymphocytic and collagenous colitis treated similarly? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Pardi DS, et al. Microscopic colitis. Reviews in Basic and Clinical Gastroenterology and Hepatology. 2011;140:1155.
- AskMayoExpert. Does surgery have a role in management of microscopic colitis? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Chetty R, et al. Lymphocytic and collagenous colitis: An overview of so-called microscopic colitis. Nature Reviews Gastroenterology and Hepatology. 2012; 9:209.
- AskMayoExpert. Should all patients with microscopic colitis be tested for celiac disease? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Nutrition therapy for diarrhea. Nutrition Care Manual. American Dietetic Association. https://docs.google.com/viewer?a=v&q=cache:kL8NLFTBEt8J:nutritioncaremanual.org/vault/editor/Docs/DiarrheaNutritionTherapy_FINAL.pdf+nutrition+therapy+for+diarrhea&hl=en&gl=us&pid=bl&srcid=ADGEEShCAF64UkfWELX-_iienWkqA6SM2sk2HKe8HmEr5fOT-ZLzW9hbdwSoOuVhxjn4IykLy1popBOTKYxVT2hrPhqImrzpW_kzIhxffQ5ZNDkMp_lwP13vX8Xl1FmjaWJ5QDNzHQBg&sig=AHIEtbQw86uZbSC8HTTPMg8rQFWkFBHbPA. Accessed Nov.4, 2012.