MGUS doesn't require treatment. But your doctor is likely to recommend periodic checkups to monitor your health, probably starting six months after your diagnosis.

Watchful waiting

If you are at high risk of developing a more-serious condition, your doctor may recommend more frequent checkups so that any progression can be diagnosed and treatment started as soon as possible.

Your doctor is likely to watch for the development of signs and symptoms including:

  • Pain
  • Fatigue or weakness
  • Unintentional weight loss
  • Fever or night sweats
  • Headache, dizziness, nerve pain, or changes in vision or hearing
  • Bleeding
  • Anemia or other blood abnormalities
  • Swollen lymph nodes, liver or spleen
  • Heart and kidney problems


If you have osteoporosis, your doctor might recommend a medication (bisphosphonate) to increase bone density. Examples include alendronate (Binosto, Fosamax), risedronate (Actonel, Atelvia), ibandronate (Boniva) and zoledronic acid (Reclast, Zometa).