- Experience. Mayo Clinic hematologists diagnose and care for hundreds of patients with monoclonal gammopathy of undetermined significance (MGUS) each year. Experienced pathologists are skilled in the testing and identification of the M protein and determining its potential risk of progression to cancer.
- Research Advances. Numerous Mayo Clinic researchers are studying MGUS to better understand it and to improve treatment options. Mayo Clinic researchers developed a risk-assessment model that can predict risk of progression of monoclonal gammopathy of undetermined significance to multiple myeloma.
- Coordinated care. A specialist in blood diseases (hematologist) will oversee your care and bring in other specialists as needed, including neurologists if nerve damage is suspected, nephrologists to prevent kidney failure and dermatologists if skin lesions occur. Access to specialists, testing and treatment is available in one convenient location and can be accomplished in a few days.
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May 17, 2013
- Rajkumar SV. Diagnosis of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
- Rajkumar SV. Clinical course and management of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
- Blade J. Monoclonal gammopathies of undetermined significance. New England Journal of Medicine. 2006;355:2765.
- Rajkumar SV, et al. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: Implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clinic Proceedings. 2010;85:945.
- Therneau TM. Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition. Mayo Clinic Proceedings. 2012;87:1071.
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