Some people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders.

Doctors can't definitively predict who will go on to develop a more serious condition, but they can determine who has the greatest risk. Your doctor takes into account several factors when determining your risk, including:

  • The amount of M protein in your blood
  • The type of M protein
  • The amount of another small protein (free light chain) in your blood

Your risk of developing a more serious condition increases the longer you've had monoclonal gammopathy of undetermined significance. Also, the more risk factors you have, the higher your risk of developing a more serious condition.

Other complications associated with monoclonal gammopathy of undetermined significance include fractures and blood clots.

May. 17, 2013