Membranous nephropathy usually develops gradually, so you may not suspect that anything is wrong. As you lose protein from your blood, swelling in your legs and ankles and weight gain from excess fluid can occur. Some people experience lots of swelling from the very beginning of the disease, and others may not have any severe symptoms until they have advanced kidney disease.

Signs and symptoms of membranous nephropathy include:

  • Swelling in the legs and ankles
  • Weight gain
  • Fatigue
  • Poor appetite
  • Frothy urine
  • Elevated fat levels in the blood (hyperlipidemia)
  • Increased protein levels in the urine (proteinuria)
  • Decreased protein levels in the blood, particularly of the protein albumin

When to see a doctor

If you have blood in your urine, persistent swelling in your legs and ankles, or increased blood pressure, make an appointment to see a doctor.

Oct. 21, 2014

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