Membranous nephropathy usually develops gradually, so people often don't notice anything wrong. As you lose more protein from your blood, you may notice swelling in your legs and ankles and weight gain from excess fluid. Some people experience lots of swelling from the very beginning of the disease. Most people do not have any severe symptoms until their kidney disease is advanced. Signs and symptoms include:

  • Swelling in the legs and ankles
  • Weight gain
  • Fatigue
  • Poor appetite
  • Trouble sleeping
  • Increased urination, especially at night
  • Blood clots
  • Infections
  • Frothy urine

When to see a doctor

If you notice blood in your urine or swelling in your legs and ankles, or if your blood pressure goes up, you should see a doctor.

Oct. 12, 2011