Complications associated with membranous nephropathy include:
Oct. 21, 2014
- High cholesterol. Levels of cholesterol and triglycerides are often high in people with membranous nephropathy, which greatly increases the risk of heart disease.
- Blood clots. With proteinuria, you may lose proteins that help prevent clotting from your blood into your urine. This makes you more prone to having blood clots develop in deep veins or blood clots that travel to your lungs.
- High blood pressure. Waste buildup in your blood (uremia) and salt retention can raise blood pressure.
- Infections. You're more susceptible to infections when proteinuria causes you to lose immune system proteins (antibodies) that protect you from infection.
- Nephrotic syndrome. High protein levels in the urine, low protein levels in the blood, high blood cholesterol, and swelling (edema) of the eyelids, feet and abdomen can lead to nephrotic syndrome — a cluster of signs and symptoms that affect your kidneys' filtering ability.
- Acute kidney failure. In cases of severe damage to the kidneys' filtering units (glomeruli), waste products may build up quickly in your blood. You may need emergency dialysis to remove extra fluids and waste from your blood.
- Chronic kidney disease. Your kidneys may gradually lose function over time to the point where you need dialysis or a kidney transplant.
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- Nephrotic syndrome in adults. National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC). http://kidney.niddk.nih.gov/kudiseases/pubs/nephrotic/. Accessed Aug. 28, 2014.
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- Glomerular filtration rate (GFR). National Kidney Foundation. http://www.kidney.org/atoz/content/gfr.cfm. Accessed Sept. 3, 2014.
- Hogan J, et al. Diagnostic tests and treatment options in glomerular disease: 2014 update. American Journal of Kidney Diseases. 2014;63:656.
- Hofstra JM, et al. Treatment of idiopathic membranous nephropathy. Nature Reviews Nephrology. 2013;9:443.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. June 20, 2014.
- Fervenza FC (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 6, 2014.
- Anti-PLA2R assay guidance. The Renal Association. http://rarerenal.org/clinician-information/membranous-nephropathy-clinician-information/anti-pla2r-assay-guidance/. Accessed Sept. 15, 2014.