Mayo Clinic researchers are actively investigating new ways to identify and treat people with Lynch syndrome, as well as novel opportunities for cancer prevention. Mayo doctors are seeking to better understand and discover more of the genetic mutations that cause Lynch syndrome. Mayo Clinic discovered microsatellite instability and developed a microsatellite instability (MSI) tumor test for identifying Lynch syndrome, helping doctors make important decisions on the timing and delivery of care for people with the disease.
See a list of publications by Mayo doctors on Lynch syndrome on PubMed, a service of the National Library of Medicine.
Mar. 10, 2012
- Genetics of colorectal cancer (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/healthprofessional. Accessed Jan. 24, 2012.
- Lindor NM, et al. Concise handbook of familial cancer susceptibility syndromes. Journal of the National Cancer Institute Monographs. 2008;38:1.
- Colorectal cancer screening. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Jan. 31, 2012.
- Lindor NM, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: A systematic review. Journal of the American Medical Association. 2006;296:1507.
- Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:180.
- Backes FJ, et al. Lynch syndrome. Clinical Obstetrics and Gynecology. 2011;54:199.
- Making sense of your genes: A guide to genetic counseling. National Society of Genetic Counselors. http://www.nsgc.org/client_files/GuidetoGeneticCounseling.pdf. Accessed Jan. 24, 2012.
- Kaltenbach T, et al. Image-enhanced endoscopy is critical in the detection, diagnosis and treatment of non-polypoid colorectal neoplasms. Gastrointestinal Endoscopy Clinics of North America. 2010;20:471.
- Pande M, et al. Smoking and colorectal cancer in Lynch syndrome: Results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center. 2010;16:1331.
- Burn J, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. Lancet. 2011;378:2081.
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