Mayo Clinic researchers are actively investigating new ways to identify and care for people with Lynch syndrome, as well as novel opportunities for cancer prevention.
Mayo Clinic doctors have made many important discoveries that have contributed to the improved care of people with Lynch syndrome. For instance, Mayo Clinic researchers were among the first to recognize microsatellite instability in cancer cells and developed a microsatellite instability (MSI) tumor test for identifying Lynch syndrome in people with colon cancer. MSI tumor testing helps identify which cancers are most likely to be caused by Lynch syndrome.
See a list of publications by Mayo Clinic authors on Lynch syndrome on PubMed, a service of the National Library of Medicine.
March 13, 2015
- Genetics of colorectal cancer (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/healthprofessional. Accessed Feb. 17, 2015.
- Lindor NM, et al. Concise handbook of familial cancer susceptibility syndromes. Journal of the National Cancer Institute Monographs. 2008;38:1.
- Genetic/familial high-risk assessment: Colorectal. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Feb. 17, 2015.
- Lindor NM, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: A systematic review. Journal of the American Medical Association. 2006;296:1507.
- Giardiello FM, et al. Guidelines on genetic evaluation and management of Lynch syndrome: A consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2014;147:502.
- Syngal S, et al. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. American Journal of Gastroenterology. 2015;110:223.
- AskMayoExpert. Lynch syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Making sense of your genes: A guide to genetic counseling. Genetic Alliance. http://www.geneticalliance.org/publications/guidetogeneticcounseling. Accessed Feb. 17, 2015.
- Lynch HT, et al. Milestones of Lynch syndrome: 1895-2015. Nature Reviews Cancer. http://www.nature.com/nrc/journal/vaop/ncurrent/abs/nrc3878.html. Accessed Feb. 17, 2015.
- Thibodeau SN, et al. Microsatellite instability in cancer of the proximal colon. Science. 1993;260:816.
- Vasen HF, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): Recommendations by a group of European experts. Gut. 2013; 62:812.
- Burn J, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. The Lancet. 2011;378:2081.
- Lindor NM. Lynch syndrome 101 (years, that is). American Society of Clinical Oncology. http://meetinglibrary.asco.org/content/114000027-144. Accessed Feb. 20, 2015.
- Lindor NM (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. Feb. 19, 2015.