Lichen planus on the skin often clears up on its own in a couple years or less. If the disease affects your mucous membranes, it tends to be more resistant to treatment and prone to recur.
Medications and other treatments might help relieve itching, reduce discomfort and promote healing. Talk with your doctor to weigh the potential benefits against possible side effects of treatment.
The first choice for treatment of lichen planus is usually a prescription corticosteroid cream or ointment, to help reduce inflammation. If that doesn't help and your condition is severe or widespread, your doctor might suggest a corticosteroid pill, either alone or with the cream or ointment. If you still don't see improvement, your doctor might suggest a corticosteroid injection.
Common side effects of topical corticosteroids include skin irritation or thinning where the cream is applied, oral thrush and upset stomach. Corticosteroids are considered safe when taken as directed and for short-term use.
Immune response medicines
Medications that suppress or modify your body's immune response may be used as ointments, gels or oral medication. For example, topical calcineurin inhibitors can be particularly helpful in managing lichen planus of mucous membranes. Examples include tacrolimus (Protopic) and pimecrolimus (Elidel).
Antihistamines act against a protein called histamine that is involved in inflammation. An oral or topical antihistamine may relieve itching or pain associated with lichen planus.
Light therapy (phototherapy) may help clear up lichen planus affecting the skin. The most common phototherapy for lichen planus uses ultraviolet B (UVB) light, which penetrates only the upper layer of skin (epidermis).
There is some risk of "sunburn" with this treatment. Phototherapy using ultraviolet A (UVA) light in combination with the medication psoralen also may be effective, though it carries a small long-term risk of skin cancer and cataracts.
Light therapy usually requires two to three treatments a week for several weeks.
If your condition doesn't respond to corticosteroids or light therapy, your doctor might prescribe a retinoid. Retinoids are synthetic versions of vitamin A that can be applied to the skin or taken by mouth. Retinoid lotion may be an effective treatment, but it can irritate the skin, causing dryness, redness and peeling.
Retinoids can cause birth defects, so these drugs aren't recommended for women who are pregnant or may become pregnant. If you're pregnant or nursing, your doctor may opt to delay topical retinoid therapy or choose a different treatment.
Dealing with triggers
If your doctor suspects that your lichen planus is related to hepatitis C infection, an allergen or a drug you take, he or she will recommend steps to address the trigger. For example, you may need to switch medications or avoid offending allergens. Your doctor may refer you to an allergist or, in the case of a hepatitis C infection, a specialist in liver disease (hepatologist) for further treatment.
A number of small studies indicate the possible benefit of vitamins A and B in treating lichen planus of the skin, but further research is needed.
A couple of small clinical trials have suggested the benefit of aloe vera gel for treating lichen planus of the mouth and vulva.
Talk with your doctor before trying an alternative treatment for lichen planus. Some alternative medicines or vitamin supplements result in serious adverse reactions when combined with prescription medicines.