Diagnosis

People who are diagnosed with Lewy body dementia, also known as LBD, have a gradual decline in the ability to think. They also have at least two of the following:

  • Varying alertness and thinking function.
  • Repeated visual hallucinations.
  • Movement symptoms.
  • REM sleep behavior disorder, in which people act out their dreams during sleep.

Other symptoms that support a Lewy body dementia diagnosis include problems with the autonomic nervous system. When this happens, the body isn't able to regulate blood pressure, heart rate, body temperature and sweating.

Sensitivity to medicines that treat psychosis also supports a diagnosis. This is particularly true for medicines such as haloperidol (Haldol). Antipsychotic medicines aren't used for people with LBD because they can make symptoms worse.

No single test can diagnose Lewy body dementia. The diagnosis is based on your symptoms and by ruling out other conditions. You might need the following tests.

Neurological and physical exam

Your healthcare professional may check for signs of Parkinson's disease, strokes, tumors or other conditions. A neurological exam tests:

  • Reflexes.
  • Strength.
  • Walking.
  • Muscle tone.
  • Eye movements.
  • Balance.
  • Sense of touch.

Test of mental abilities

A short form of this test, which assesses memory and thinking skills, can be done in less than 10 minutes. The test doesn't usually distinguish between Lewy body dementia and Alzheimer's disease. But the test can determine whether you have cognitive impairment. Longer tests that take several hours also help identify LBD.

Blood tests

These can rule out physical causes of changes in brain function, such as vitamin B-12 deficiency or an underactive thyroid gland.

Brain scans

Your healthcare professional might order an MRI or CT scan to look for signs of a stroke or bleeding and to rule out a tumor. Dementias are diagnosed based on medical history and physical exam, but imaging results can suggest whether someone has Alzheimer's disease or LBD.

If the diagnosis is unclear or the symptoms aren't typical, you may need other imaging tests. These imaging tests may support a diagnosis of Lewy body dementia:

  • Fluorodeoxyglucose PET brain scans, which assess brain function.
  • Single-photon emission computerized tomography (SPECT) or PET imaging. These tests can show reduced dopamine transporter uptake in the brain. This can help diagnose Lewy body dementia.

Sleep test

You may need a sleep test called a polysomnogram to check for REM sleep behavior disorder.

Autonomic function test

You may need a test that checks if your heart rate, blood pressure or other automatic functions are stable.

Heart test

In some countries, healthcare professionals also might order a heart test called myocardial scintigraphy. This checks the blood flow to your heart for signs that might point to Lewy body dementia. However, the test isn't used in the United States.

Emerging biomarkers

Studies are ongoing into other indicators of Lewy body dementia. Groups are studying a test that detects clumps of proteins linked to LBD called alpha-synuclein in samples of cerebrospinal fluid obtained through a spinal tap. They're also testing skin samples for alpha-synuclein in people with Lewy body dementia. These biomarkers are currently available but not yet widely used. They might eventually enable early diagnosis of Lewy body dementia before the full disease develops.

Treatment

There's no cure for Lewy body dementia, also known as LBD, but many of the symptoms can improve with targeted treatments.

Medicines

These medicines can help improve Lewy body dementia symptoms.

  • Cholinesterase inhibitors. These Alzheimer's disease medicines increase levels of chemical messengers in the brain, known as neurotransmitters. These chemical messengers are believed to be important for memory, thought and judgment. Medicines include rivastigmine (Exelon), donepezil (Aricept, Adlarity) and galantamine (Zunveyl). They may help improve alertness and thinking and may reduce hallucinations and other behavioral symptoms.

    Possible side effects include stomach upset, muscle cramps and urinating more often. Cholinesterase inhibitors also can increase the risk of certain cardiac arrhythmias.

    In some people with moderate or severe dementia, an N-methyl-d-aspartate (NMDA) receptor antagonist called memantine (Namenda) might be added to the cholinesterase inhibitor.

  • Parkinson's disease medicine. The combination medicine carbidopa-levodopa (Sinemet, Duopa, others) can help reduce rigid muscles and slow movement. However, this medicine also can increase confusion, hallucinations and delusions.
  • Medicines to treat other symptoms. Your healthcare professional might prescribe medicines to treat other symptoms, such as trouble sleeping or movement symptoms.

Certain medicines can worsen memory. Don't take sleep aids that contain diphenhydramine (Advil PM, Aleve PM) or medicines that treat urinary urgency, such as oxybutynin (Oxytrol).

Limit sedatives and sleeping medicines. Talk to a healthcare professional about whether any of the medicines you take might make your memory worse.

Antipsychotic medicines can cause very bad confusion, movement symptoms, sedation and sometimes death in people with LBD. Very rarely, certain second-generation antipsychotics, such as quetiapine (Seroquel) or clozapine (Clozaril, Versacloz) might be prescribed for a short time at a low dose. But they're offered only if the benefits outweigh the risks.

Therapies

Because antipsychotic medicines can worsen LBD symptoms, it might be helpful to first try other approaches, such as:

  • Tolerate the behavior. Some people with Lewy body dementia aren't distressed by hallucinations. If this is true, the side effects of medicines to treat them might be worse than the hallucinations themselves.
  • Modify the environment. Reducing clutter and noise can make it easier for someone with dementia to function. Caregivers' responses also sometimes worsen behavior. Avoid correcting and quizzing a person with dementia. Offer reassurance and validation of his or her concerns.
  • Create daily routines and keep tasks simple. Break tasks into easier steps and focus on successes, not failures. Structure and routine during the day can be less confusing.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Symptoms and how quickly they worsen are different for everyone with Lewy body dementia. Caregivers and spouses of people with Lewy body dementia, known as care partners, may need to adapt the following tips:

  • Speak clearly and simply. Maintain eye contact and speak slowly in simple sentences. Don't rush the response. Present only one idea or instruction at a time. Use gestures and cues, such as pointing to objects.
  • Encourage exercise. Exercise improves physical function, behavior and depression. Some research shows exercise might slow cognitive decline in people with dementia.
  • Provide mind stimulation. Playing games, completing crossword puzzles and doing other activities that involve thinking might help slow mental decline in people with dementia. Encourage artistic and creative activities, such as painting, singing or making music.
  • Create opportunities for social activity. Talk to friends. Participate in religious services.
  • Establish bedtime rituals. Behavior symptoms can worsen at night. Create calming bedtime rituals without the distraction of television, meal cleanup and active family members. Leave night-lights on to prevent disorientation.

Limit caffeine during the day. Discourage daytime napping and offer activities to stay active during the day. This might help prevent nighttime restlessness.

Alternative medicine

Frustration and anxiety can worsen dementia symptoms. To promote relaxation, consider:

  • Music therapy, which involves listening to soothing music.
  • Pet therapy, which involves the use of animals to improve moods and behaviors in people with dementia.
  • Aromatherapy, which uses fragrant plant oils.
  • Massage therapy.

Coping and support

People with Lewy body dementia often have a mixture of emotions. The person may feel confused, frustrated, angry or afraid. They may not be certain about the future and may feel grief and depression. Offer support by listening. Provide assurance that the person can still enjoy life. Be positive and do your best to help the person retain dignity and self-respect.

If you're a caregiver or care partner for someone with Lewy body dementia, watch the person closely. Make sure the person doesn't fall, lose consciousness or have a bad reaction to medicines. Provide reassurance during times of confusion, delusions or hallucinations.

Looking after yourself

Caring for a person with Lewy body dementia can be exhausting physically and emotionally. You may have anger, guilt, frustration, discouragement, worry, grief or social isolation. Help prevent caregiver burnout by:

  • Asking friends or other family members for help when you need it. Consider in-home health services to help you care for the person with Lewy body dementia.
  • Exercising regularly and eating a healthy diet.
  • Learning about the disease. Ask questions of healthcare professionals, social workers and others on the care team.
  • Joining a support group.

Many people with Lewy body dementia and their families benefit from counseling or local support groups. Contact your local agencies on health or aging to connect with support groups, healthcare professionals, resources and referrals. They also can recommend home care agencies, supervised living facilities, a phone help line and educational seminars.

Preparing for your appointment

You might first discuss your symptoms with a healthcare professional who may refer you to a doctor trained in dementia. This is usually a doctor trained in brain and nervous system conditions, called a neurologist, or a doctor trained in mental health conditions, called a psychiatrist.

Ask a friend or family member to come to the appointment, if possible. This person can help you remember the information you're given and give your healthcare professional information about you. Here's some information to help you get ready for your appointment.

What you can do

Make a list of:

  • Your symptoms and when they began.
  • All medicines, vitamins or other supplements you take, including doses.
  • Questions to ask.

What to expect from your doctor

You, your spouse, partner or close friend are likely to be asked a number of questions about:

  • Changes in your memory, personality and behavior.
  • Visual hallucinations.
  • Your history of stroke, depression, alcohol use disorder, head trauma or other neurological disorders.
June 21, 2025
  1. Lewy body dementia. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/All-Disorders/Dementia-Lewy-Bodies-Information-Page. Accessed Feb. 22, 2025.
  2. McFarland N. Clinical features and diagnosis of dementia with Lewy bodies. https://www.uptodate.com/contents/search. Accessed Feb. 22, 2025.
  3. Budson AE, et al. Dementia with Lewy bodies. In: Memory Loss, Alzheimer's Disease, and Dementia. 3rd ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 22, 2025.
  4. Prasad S, et al. Recent advances in Lewy body dementia: A comprehensive review. Disease-a-Month. 2023; doi:10.1016/j.disamonth.2022.101441.
  5. Clinical management. Lewy Body Dementia Association. https://www.lbda.org/clinical-management/. Accessed Feb. 22, 2025.
  6. Understanding behavioral changes in dementia. Lewy Body Dementia Association. https://www.lbda.org/understanding-behavioral-changes-in-dementia/. Accessed Feb. 22, 2025.
  7. Galvin JE. Lewy body dementia. Continuum. 2024; doi:10.1212/CON.0000000000001496.
  8. Ferri FF. Dementia with Lewy bodies. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed Feb. 22, 2025.
  9. Press D. Management of neuropsychiatric symptoms of dementia. https://www.uptodate.com/search/contents. Accessed Feb. 22, 2025.
  10. Donaghy PC, et al. Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis. Alzheimer's & Dementia. 2023; doi:10.1002/alz.13105.
  11. Khan SA, et al. Insights into the management of Lewy body dementia: A scoping review. Annals of Medicine and Surgery. 2024; doi:10.1212/CON.0000000000001496.
  12. Luo G, et al. Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia — A network meta-analysis of randomized controlled trials. Frontiers in Aging: Neuroscience. 2023; doi:10.3389/fnagi.2023.1131744.
  13. Dementia with Lewy bodies and Parkinson disease dementia. Merck Manual Professional Version. https://www.merckmanuals.com/professional/neurologic-disorders/delirium-and-dementia/dementia-with-lewy-bodies-and-parkinson-disease-dementia. Accessed Feb. 22, 2025.
  14. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Dec. 24, 2024.
  15. Diphenhydramine oral. Facts & Comparisons eAnswers. https://fco.factsandcomparisons.com. Accessed March 2, 2025.
  16. Kobayashi S, et al Analysis of adverse events of cholinesterase inhibitors and NMDA receptor antagonists on arrhythmias using the Japanese Adverse Drug Event Report database. Drugs — Real World Outcomes. 2023; doi:10.1007/s40801-023-00362-6.
  17. Lewy body dementia: Causes, symptoms and diagnosis. National Institute on Aging. https://www.nia.nih.gov/health/lewy-body-dementia/lewy-body-dementia-causes-symptoms-and-diagnosis. Accessed Feb. 22, 2025.
  18. Compagnoni GM, et al. The role of 123-I-MIBG cardiac scintigraphy in the differential diagnosis between dementia with Lewy bodies and Alzheimer's disease. Neurological Sciences. 2024; doi:10.1007/s10072-024-07476-x.
  19. Arnold MR, et al. A-synuclein seed amplification in CSF and brain from patients with different brain distributions of pathological a-synuclein in the context of co-pathology and non-LBD diagnoses. Annals of Neurology. 2022; doi:10.1002/ana.26453.
  20. Gibbons CH, et al. Skin biopsy detection of phosphorylated a-synuclein in patients with synucleinopathies. JAMA. 2024; doi:10.1001/jama.2024.0792.