You may be able to prevent leukoplakia if you avoid all tobacco products or alcohol use. Talk to your doctor about methods to help you quit. If you continue to smoke or chew tobacco or drink alcohol, have frequent dental checkups. Oral cancers are usually painless until fairly advanced, so quitting tobacco and alcohol is a better prevention strategy.
If you have a weakened immune system, you may not be able to prevent hairy leukoplakia, but identifying it early can help you receive appropriate treatment.