Below are current clinical trials.11 studies in Kidney cancer
(open studies only).
Filter this list of studies by location, status and more.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla.
The purpose of the study is to test different doses of X4P-001 given alone and in combination with axitinib in patients diagnosed with advanced renal cell carcinoma. The goals of the study are to determine the safety and tolerability of X4P-001, as well as the potential effect it may have on the body and the cancer tumor.
The purpose of this study is to demonstrate that rivaroxaban is superior to placebo for reducing the risk of lower extremity proximal deep vein thrombosis (DVT), asymptomatic lower extremity proximal DVT, symptomatic upper extremity DVT, symptomatic non-fatal pulmonary embolism (PE), incidental PE, and venous thromboembolism (VTE)-related death in ambulatory adult patients with various cancer types receiving systemic cancer therapy who are at high risk of developing a VTE.
The purpose of this study is to evaluate the anti-tumor activity and safety of avelumab in combination with axitinib compared to sunitinib alone, when given as a first-line treatment, to patients with advanced renal cell cancer.
Scottsdale/Phoenix, Ariz., Rochester, Minn., Jacksonville, Fla.
RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth by blocking blood flow to the tumor. Drugs used in chemotherapy, such as hypoxia-activated prodrug TH-302, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sorafenib tosylate together with hypoxia-activated prodrug TH-302 may kill more tumor cells. PURPOSE: This phase I/II trial studies the side effects and best dose of giving sorafenib tosylate together with hypoxia-activated prodrug TH-302 and to see how well they work in treating patients with advanced kidney cancer or liver cancer that cannot be removed by surgery.
The purpose of this study is to evaluate the safety, tolerability and effectiveness of HBI-8000 when combined with a standard dose and regimen of nivolumab.
The purpose of this study is to see if getting chemotherapy with Gemcitabine and Cisplatin for four 21 day cycles for a total of 12 weeks can help shrink the tumor before undergoing surgery for kidney cancer.
This laboratory study is looking at kidney tumors in young patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer. It may also help the study of cancer in the future.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.
GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.
The goal of this study is to create and maintain a comprehensive genitourinary disease biospecimens bank consisting of tissue, kidney stones and bodily fluid (such as blood or urine, but not limited to this) samples.
Phase 1b: To evaluate safety and tolerability and determine a recommended phase 2 dose for TRC105 when added to standard dose axitinib in patients with advanced renal cell carcinoma. Phase 2: To estimate the PFS of patients with advanced or metastatic RCC by RECIST 1.1 criteria in patients treated with axitinib and TRC105 compared to those treated with axitinib alone, following failure of one prior VEGF TKI
Aug. 15, 2017
- NCCN Guidelines Version 2.2017: Kidney cancer. National Comprehensive Cancer Network. 2016.
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- American Cancer Society. What is kidney cancer? https://www.cancer.org/cancer/kidney-cancer/about/what-is-kidney-cancer.html. Accessed Feb. 8, 2017.
- American Cancer Society. Causes, risk factors, and prevention. https://www.cancer.org/cancer/kidney-cancer/causes-risks-prevention.html. Accessed Feb 8, 2017.
- Ho TH, et al. Genetic kidney cancer syndromes. Journal of the National Comprehensive Cancer Network. 2014;12:1347.
- Fay AP, et al. Whole-exome sequencing in two extreme phenotypes of response to VEGF-targeted therapies in patients with metastatic clear cell renal carcinoma. Journal of the National Comprehensive Cancer Network. 2016;14:820.
- Drugs approved for kidney (renal cell) cancer. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/kidney. Accessed Feb. 8, 2017.
- Kardos SV, et al. Association of type of renal surgery and access to robotic technology for kidney cancer: Results from a population-based cohort. BJU International. 2014;114:549.
- George S, et al. Safety and efficacy of nivolumab in patients with metastatic renal cell carcinoma treated beyond progression: A subgroup analysis of a randomized clinical trial. JAMA Oncology. 2016;2:1179.
- Atkins MG. Overview of the treatment of renal cell carcinoma. http://www.uptodate.com/home. Accessed Feb. 8, 2017.
- American Cancer Society. What are the key statistics about kidney cancer? https://www.cancer.org/cancer/kidney-cancer/about/key-statistics.html. Accessed Feb. 8, 2017.
- American Cancer Society. Kidney cancer: Early detection, diagnosis, and staging. https://www.cancer.org/cancer/kidney-cancer/detection-diagnosis-staging.html. Accessed Feb. 8, 2017.
- American Cancer Society. Treating kidney cancer. https://www.cancer.org/cancer/kidney-cancer/treating.html. Accessed Feb. 8, 2017.
- Ho, TH (expert answer). Mayo Clinic, Phoenix, Ariz. Feb. 11, 2017.
- National Institutes of Health. NIH clinical research trials and you. https://www.nih.gov/health-information/nih-clinical-research-trials-you. Accessed March 13, 2017.
- Leibovich, BC (expert answer). Mayo Clinic, Rochester, Minn. May 30, 2017.
- Richie JP, et al. Role of surgery in patients with metastatic renal cell carcinoma. http://www.uptodate.com/home. Accessed March 16, 2017.