CausesBy Mayo Clinic Staff
Doctors don't know what causes fibromyalgia, but it most likely involves a variety of factors working together. These may include:
- Genetics. Because fibromyalgia tends to run in families, there may be certain genetic mutations that may make you more susceptible to developing the disorder.
- Infections. Some illnesses appear to trigger or aggravate fibromyalgia.
- Physical or emotional trauma. Post-traumatic stress disorder has been linked to fibromyalgia.
Why does it hurt?
Researchers believe repeated nerve stimulation causes the brains of people with fibromyalgia to change. This change involves an abnormal increase in levels of certain chemicals in the brain that signal pain (neurotransmitters). In addition, the brain's pain receptors seem to develop a sort of memory of the pain and become more sensitive, meaning they can overreact to pain signals.
April 29, 2014
- Fibromyalgia. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Fibromyalgia/default.asp. Accessed April 8, 2014.
- Clauw DJ, et al. The science of fibromyalgia. Mayo Clinic Proceedings. 2011;86:907.
- Arnold LM, et al. A framework for fibromyalgia management for primary care providers. Mayo Clinic Proceedings. 2012;87:488.
- Goldenberg DL. Clinical manifestations and diagnosis of fibromyalgia in adults. http://www.uptodate.com/home. Accessed April 8, 2014.
- AskMayoExpert. Fibromyalgia and myofascial pain. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Vincent A, et al. Prevalence of fibromyalgia: A population-based study in Olmsted County, Minnesota, utilizing the Rochester Epidemiology Project. Arthritis Care & Research. 2013;65:786.
- Goldenberg DL. Pathogenesis of fibromyalgia. http://www.uptodate.com/home. Accessed April 8, 2014.
- Goldenberg DL. Treatment of fibromyalgia in adults not responsive to initial therapies. http://www.uptodate.com/home. Accessed April 8, 2014.
- Yunus MB, et al. Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis & Rheumatology. 1985;28:138.
- McLeod JD. Juvenile fibromyalgia syndrome and improved recognition by pediatric primary care providers. Journal of Pediatric Health Care. 2014;28:e9.
- Kashikar-Zuck S, et al. Juvenile fibromyalgia: Current status of research and future developments. Nature Reviews Rheumatology. 2014;10:89.
- Kashikar-Zuck S, et al. Long-term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics. 2014;133:e592.
- Kimura Y, et al. Fibromyalgia in children and adolescents: Clinical manifestations and diagnosis. http://www.uptodate.com/home. Accessed April 4, 2014.
- Kimura Y, et al. Fibromyalgia in children and adolescents: Treatment and prognosis. http://www.uptodate.com/home. Accessed April 4, 2014.