IgA nephropathy (nuh-FROP-uh-thee), also known as Berger's disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This results in local inflammation that, over time, may hamper your kidneys' ability to filter wastes from your blood.

IgA nephropathy usually progresses slowly over many years, but the course of the disease in each person is uncertain. Some people leak blood in their urine without developing problems, some eventually achieve complete remission, and others develop end-stage kidney failure.

No cure exists for IgA nephropathy, but certain medications can slow its course. Keeping your blood pressure under control and reducing your cholesterol levels also slow disease progression.

IgA nephropathy care at Mayo Clinic

Aug. 04, 2017
  1. Gilbert SJ, et al. Immunoglobulin A nephropathy and related disorders. In: National Kidney Foundation's Primer on Kidney Diseases. 6th ed. Philadelphia, PA.: Elsevier/Saunders; 2014. http://www.clinicalkey.com. Accessed Jan. 27, 2016.
  2. Roberts IS. Pathology of IgA nephropathy. Nature Reviews Nephrology. 2014;10:445.
  3. IgA nephropathy. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/kidney-disease/iga-nephropathy/Pages/facts.aspx . Accessed Jan. 29, 2016.
  4. Immunoglobulin A nephropathy (IgA nephropathy). Merck Manuals Professional Edition. https://www.merckmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy-(iga-nephropathy). Accessed Jan. 29, 2016.
  5. IgA nephropathy. National Organization for Rare Disorders. http://rarediseases.org/rare-diseases/iga-nephropathy/. Accessed Jan. 29, 2016.
  6. IgA nephropathy. National Kidney Foundation. https://www.kidney.org/atoz/content/iganeph. Accessed Jan. 29, 2016.
  7. Barratt J, et al. Clinical presentation and diagnosis of IgA nephropathy. http://www.uptodate.com/home. Accessed Jan. 31, 2016.
  8. Wyatt RJ, et al. IgA nephropathy. The New England Journal of Medicine. 2013;368:2402.
  9. Vecchio M, et al. Immunosuppressive agents for treating IgA nephropathy. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003965.pub2/abstract. Accessed Jan. 31, 2016.
  10. NKF PEERS. National Kidney Foundation. https://www.kidney.org/patients/peers/. Accessed Jan. 29, 2016.
  11. Cook AJ. EPSi. Mayo Clinic, Rochester, Minn. Jan. 6, 2016.
  12. Your guide to lowering blood pressure. National Institutes of Health. http://www.nhlbi.nih.gov/health/resources/heart/hbp-guide-to-lower. Accessed Jan. 29, 2016.
  13. Fervenza FC (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 16, 2016.