IgA nephropathy is often detected after you notice blood in your urine or when a routine test shows you have protein or blood in your urine. These could be signs of several types of kidney disease. To identify your problem, these tests may be performed:
- Urine test. Blood or protein in the urine may be the first sign of IgA nephropathy. This may be discovered as part of a routine checkup. If your doctor suspects that you have problems with your kidneys, you may need to collect your urine for a 24-hour period for additional kidney function tests.
- Blood tests. If you have kidney disease, such as IgA nephropathy, a blood test may show increased blood levels of the waste product creatinine.
- Kidney biopsy. The only way for your doctor to confirm a diagnosis of IgA nephropathy is with a kidney biopsy. This procedure involves using a special biopsy needle to extract small pieces of kidney tissue for microscopic examination to determine if there are IgA deposits in the glomeruli.
- Iothalamate clearance test. Your doctor may also recommend an iothalamate clearance test, which uses a special contrast agent to track how well your kidneys are filtering wastes.
Aug. 04, 2017
- Gilbert SJ, et al. Immunoglobulin A nephropathy and related disorders. In: National Kidney Foundation's Primer on Kidney Diseases. 6th ed. Philadelphia, PA.: Elsevier/Saunders; 2014. http://www.clinicalkey.com. Accessed Jan. 27, 2016.
- Roberts IS. Pathology of IgA nephropathy. Nature Reviews Nephrology. 2014;10:445.
- IgA nephropathy. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/kidney-disease/iga-nephropathy/Pages/facts.aspx . Accessed Jan. 29, 2016.
- Immunoglobulin A nephropathy (IgA nephropathy). Merck Manuals Professional Edition. https://www.merckmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy-(iga-nephropathy). Accessed Jan. 29, 2016.
- IgA nephropathy. National Organization for Rare Disorders. http://rarediseases.org/rare-diseases/iga-nephropathy/. Accessed Jan. 29, 2016.
- IgA nephropathy. National Kidney Foundation. https://www.kidney.org/atoz/content/iganeph. Accessed Jan. 29, 2016.
- Barratt J, et al. Clinical presentation and diagnosis of IgA nephropathy. http://www.uptodate.com/home. Accessed Jan. 31, 2016.
- Wyatt RJ, et al. IgA nephropathy. The New England Journal of Medicine. 2013;368:2402.
- Vecchio M, et al. Immunosuppressive agents for treating IgA nephropathy. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003965.pub2/abstract. Accessed Jan. 31, 2016.
- NKF PEERS. National Kidney Foundation. https://www.kidney.org/patients/peers/. Accessed Jan. 29, 2016.
- Cook AJ. EPSi. Mayo Clinic, Rochester, Minn. Jan. 6, 2016.
- Your guide to lowering blood pressure. National Institutes of Health. http://www.nhlbi.nih.gov/health/resources/heart/hbp-guide-to-lower. Accessed Jan. 29, 2016.
- Fervenza FC (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 16, 2016.
IgA nephropathy (Berger's disease)