IgA nephropathy usually doesn't cause symptoms in the early stages. The disease can go unnoticed for decades and is sometimes first suspected when routine tests reveal protein and red blood cells in your urine that can't be seen without a microscope (microscopic hematuria).
Signs and symptoms of IgA nephropathy when kidney function is impaired include:
- Cola- or tea-colored urine (caused by red blood cells in the urine)
- Repeated episodes of cola- or tea-colored urine, sometimes even visible blood in your urine, usually during or after an upper respiratory or other type of infection
- Pain in the side(s) of your back below your ribs (flank)
- Foam in the toilet water from protein in your urine
- Swelling (edema) in your hands and feet
- High blood pressure
When to see a doctor
Make an appointment with your doctor if you notice blood in your urine. Urinary bleeding may be caused by strenuous exercise, some foods, medications or a urinary tract infection. But prolonged or repeated bleeding may indicate a serious medical problem and should always be evaluated. Also see your doctor if your urine is foamy or if you develop sudden swelling in your hands and feet.
April 19, 2013
IgA nephropathy. National Institute of Diabetes and Digestive and Kidney Diseases. http://kidney.niddk.nih.gov/kudiseases/pubs/iganephropathy/. Accessed March 15, 2013.
- Nephrotic syndrome. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec17/ch235/ch235b.html. Accessed March 15, 2013.
- Barratt J, et al. Clinical presentation and diagnosis of IgA nephropathy. http://www.uptodate.com/home. Accessed March 15, 2013.
- Barratt J, et al. Pathogenesis of IgA nephropathy. http://www.uptodate.com/home. Accessed March 15, 2013.
- Anderson CF (expert opinion). Mayo Clinic, Rochester, Minn. March 18, 2013.
- Cattran DC, et al. Treatment and prognosis of IgA nephropathy. http://www.uptodate.com/home. Accessed March 15, 2013.
- Lv J, et al. Corticosteroid therapy in IgA nephropathy. Journal of the American Society of Nephrology. 2012;23:1108.
- IgA nephropathy. National Kidney Foundation. http://www.kidney.org/atoz/content/iganeph.cfm. Accessed March 15, 2013.
- Your guide to lowering blood pressure. National Institutes of Health. http://www.nhlbi.nih.gov/health/public/heart/hbp/hbp_low/index.htm. Accessed March 16, 2013.
- Miller HL. Decision Support System. Mayo Clinic, Rochester, Minn. March 8, 2013.
- PEERS Lending Support. National Kidney Foundation. http://www.kidney.org/patients/peers/index.cfm. Accessed March 16, 2013.
- Fervenza FC (expert opinion). Mayo Clinic, Rochester, Minn. March 18, 2013.
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