Though the cause of hypospadias is unknown, both environmental and genetic factors have been associated with the condition, including:

  • Family history. This condition is more common in infants with a family history of hypospadias.
  • Maternal age over 40. Some research suggests that there may be an increased risk of hypospadias in infant males born to women of an advanced age.
  • Exposure to smoking and chemicals. There is some speculation about an association between a mother's exposure to pesticides and hypospadias, but further studies are needed to confirm this.
Jan. 22, 2011