Diagnosis at Mayo ClinicBy Mayo Clinic Staff
The initial goal in diagnosing hypereosinophilic syndrome is to rule out other disorders that can elevate your eosinophil count — such as a parasitic infection, allergic disease, drug reaction or autoimmune disorder. Therefore, provide your doctor with your travel history and a list of medications you're taking.
Ruling out other conditions
Based on your symptoms, your doctor will recommend certain tests. Some tests to rule out other conditions include:
- Blood tests. Blood tests may reveal autoimmunities, parasitic infections, or impaired liver or kidney function.
- Allergy tests. Environmental or food allergies can elevate your eosinophil count.
- Stool tests. Stool evaluations can detect parasitic infections that affect your eosinophil count, such as hookworm.
- Imaging tests. Chest X-rays, computerized tomography (CT) scans and echocardiograms help evaluate the condition of your heart, abdomen and lungs.
Determining the cause of your HES
If you've been diagnosed with HES, these tests may help determine the cause:
April 28, 2015
- Blood screening. This test can reveal a genetic mutation known as FIP1L1-PDGFRA, which can cause hypereosinophilic syndrome.
- Bone marrow biopsy. If your blood screen is negative for a genetic mutation, this test may be considered. Biopsies are also useful because they help exclude the possibility of other conditions.
- Hypereosinophilic syndrome (HES). American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/related-conditions/hypereosinophilic-syndrome.aspx. Accessed Jan. 29, 2015.
- AskMayoExpert. What is the definition of the hypereosinophilic syndrome? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
- Eosinophilia. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/hematology_and_oncology/eosinophilic_disorders/hyper eosinophilic_syndrome.html. Accessed Jan. 29, 2015.
- Roufosse F, et al. Clinical manifestations, pathophysiology, and diagnosis of the hypereosinophilic syndromes. http://www.uptodate.com/home. Jan. 29, 2015.
- Roufosse F, et al. Treatment of the hypereosinophilic syndromes. http://www.uptodate.com/home. Jan. 29, 2015.
- Gotlib J. World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. American Journal of Hematology. 2014; 89:325-37.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. Feb.12, 2015.
- Kita, H. Alternaria and ribonucleases in Th2-type immunity. National Institutes of Health. http://projectreporter.nih.gov/. Accessed March 17, 2015.