Overview

Huntington's disease is an inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. Huntington's disease has a broad impact on a person's functional abilities and usually results in movement, thinking (cognitive) and psychiatric disorders.

Most people with Huntington's disease develop signs and symptoms in their 30s or 40s. But the disease may emerge earlier or later in life.

When the disease develops before age 20, the condition is called juvenile Huntington's disease. An earlier emergence of the disease often results in a somewhat different set of symptoms and faster disease progression.

Medications are available to help manage the symptoms of Huntington's disease, but treatments can't prevent the physical, mental and behavioral decline associated with the condition.

Huntington’s disease care at Mayo

June 13, 2017
References
  1. Ferri FF. Huntington's disease. In: Ferri's Clinical Advisor 2017. Philadelphia, Pa.: Elsevier; 2017. https://www.clinicalkey.com. Accessed Feb. 24, 2017.
  2. Dayalu P, et al. Huntington disease: Pathogenesis and treatment. Neurologic Clinics. 2015;33:1.
  3. Huntington's disease: Hope through research. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Huntingtons-Disease-Hope-Through. Accessed Feb. 24, 2017.
  4. A physician's guide to the management of Huntington's disease. Huntington's Disease Society of America. http://hdsa.org/shop/publications/. Accessed Feb. 24, 2017.
  5. National Library of Medicine. Huntington disease. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/huntington-disease. Accessed Feb. 24, 2017.
  6. Suchowersky O. Huntington disease: Clinical features and diagnosis. http://www.uptodate.com/home. Accessed Feb. 24, 2017.
  7. Suchowersky O. Huntington disease: Management. http://www.uptodate.com/home. Accessed Feb. 24, 2017.
  8. Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Jan. 6, 2017.
  9. Knopman DS (expert opinion). Mayo Clinic, Rochester, Minn. Mar. 5, 2017.