Hives and angioedema can be caused by:

  • Foods. Many foods can trigger reactions in people with sensitivities. Shellfish, fish, peanuts, tree nuts, eggs and milk are frequent offenders.
  • Medications. Almost any medication may cause hives or angioedema. Common culprits include penicillin, aspirin, ibuprofen (Advil, Motrin IB, others), naproxen (Aleve) and blood pressure medications.
  • Common allergens. Other substances that can cause hives and angioedema include pollen, animal dander, latex and insect stings.
  • Environmental factors. Examples include heat, cold, sunlight, water, pressure on the skin, emotional stress and exercise.
  • Underlying medical conditions. Hives and angioedema also occasionally occur in response to blood transfusions, immune system disorders such as lupus, some types of cancer such as lymphoma, certain thyroid conditions, and infections with bacteria or viruses such as hepatitis, HIV, cytomegalovirus or Epstein-Barr virus.
  • Genetics. Hereditary angioedema is a rare inherited (genetic) form of the condition. It's related to low levels or abnormal functioning of certain blood proteins that play a role in regulating how your immune system functions.
Feb. 14, 2014

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