Do statins cause amyotrophic lateral sclerosis (ALS)?

Answers from Thomas Behrenbeck, M.D., Ph.D.

There's no good evidence that statins cause or trigger ALS, also known as Lou Gehrig's disease. However, there have been reports of people who have developed ALS while taking statins.

ALS is a serious neurological disorder that causes disease and death of the nerve cells in the brain and spinal cord that control voluntary muscles. ALS may begin with muscle twitching, weakness in an arm or leg, or changes in speech (dysarthria). Eventually, it affects the ability to control the muscles needed to move, speak, eat and breathe.

Statins are medications prescribed for the treatment of high cholesterol. These medications can sometimes cause muscle pain (myalgia), muscle weakness and rarely severe muscle damage (rhabdomyolysis). But these occur as a result of direct muscle damage, not damage to nerve cells.

Apr. 06, 2012 See more Expert Answers