Liver cancer

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of Predictors of Renal Insufficiency Following Orthotopic Liver Transplantation

   Rochester, Minn.

   The purpose of this study is to see if certain pre-transplant markers are able to predict how the kidney will respond after a liver transplant.

2. Immunomodulation Following Thermal Ablation of Hepatocellular Carcinoma by Radiofrequency or Microwave Ablations

   Rochester, Minn.

   The goal of the study is to identify immune responses (immune cell activation and suppression) following local ablation of liver tumors.

3. The Circulating Cell-free Genome Atlas Study

   Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.

   GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.

4. Multi-phase Dual Energy for Quantitative and Radiologic Evaluation of Chronic Liver Disease

   Rochester, Minn.

   The purpose of this study is to assess the combined impact of post-processing methods that quantify potential biomarkers of chronic liver disease (AEF, fECS) and that improve iodine signal (vMono+) on detecting liver fibrosis and hepatic masses or esophageal varices, in comparison to routine contrast-enhanced liver CT.

5. Hepatocellular Carcinoma Early Detection Strategy Study

   Rochester, Minn.

   The purpose of this study is to evaluate the usefulness of new markers found in blood that might help to diagnose of liver cancer (HCC) early among people with cirrhosis. We hope that this study will show that these new markers could identify HCC at an earlier stage where better treatment options are available.

6. A Registry of Liver Tissue for Research

   Rochester, Minn.

   The purpose of the Hepatic Tissue Research Registry is to establish a local program to procure resected liver tissue and to gather critical patient and research information that will be utilized to develop a comprehensive biomedical database. This Registry data will be made accessible to scientists at Mayo, researchers outside of Mayo who have collaborations with Mayo researchers and to further biomedical and clinical research in liver biology, toxicology, cell transplantation, liver support therapy, and pathology.

7. hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse

   Rochester, Minn.

   This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 alone or in combination with INO-9012, delivered by electroporation in subjects with high-risk solid tumor cancer with no evidence of disease after surgery and standard therapy. Subjects will be enrolled into one of six treatment arms. Subjects will be assessed according to standard of care. Restaging and imaging studies will be performed to assess disease relapse per NCCN guidelines. RECIST will be used to validate the findings in cases of relapse.

8. Detection of Circulating tumor cells (CTC) from Patients with Hepatocellular Carcinoma (HCC)

   Rochester, Minn.

   This study is being done to investigate if we can identify circulating tumor cell from the peripheral blood of patients with hepatocellular carcinoma using an investigational device, RareCyte system. The results of this test will be compared to the results of the FDA-approved CellSearch Test.