Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors). If you have hemophilia, you may bleed for a longer time after an injury than you would if your blood clotted normally.

Small cuts usually aren't much of a problem. The greater health concern is deep bleeding inside your body, especially in your knees, ankles and elbows. That internal bleeding can damage your organs and tissues, and may be life-threatening.

Hemophilia is an inherited (genetic) disorder. There's no cure yet. But with proper treatment and self-care, most people with hemophilia can maintain an active, productive lifestyle.

Signs and symptoms of hemophilia vary, depending on your level of clotting factors. If your clotting-factor level is mildly reduced, you may bleed only after surgery or trauma. If your deficiency is severe, you may experience spontaneous bleeding.

Signs and symptoms of spontaneous bleeding include:

  • Unexplained and excessive bleeding from cuts or injuries, or after surgery or dental work
  • Many large or deep bruises
  • Unusual bleeding after vaccinations
  • Pain, swelling or tightness in your joints
  • Blood in your urine or stool
  • Nosebleeds without a known cause
  • In infants, unexplained irritability

Emergency signs and symptoms of hemophilia include:

  • Sudden pain, swelling and warmth in large joints, such as knees, elbows, hips and shoulders, and in your arm and leg muscles
  • Bleeding from an injury, especially if you have a severe form of hemophilia
  • Painful, prolonged headache
  • Repeated vomiting
  • Extreme fatigue
  • Neck pain
  • Double vision

When to see a doctor

Prolonged bleeding after circumcision may be the first indication of hemophilia in a baby boy. In boys who aren't circumcised, easy bruising when the child becomes more mobile may lead to the diagnosis. The first episode of bleeding generally occurs by the time a child is 2 years old.

If your child bruises easily, see your doctor. If your child has heavy bleeding that can't be stopped after an injury, seek emergency medical care.

If you're pregnant or considering pregnancy, and have a family history of hemophilia, talk to your doctor. You may be referred to a specialist in medical genetics or bleeding disorders, who can help you determine if you are a carrier of hemophilia. If you are a carrier, it's possible to determine during pregnancy if the fetus is affected by hemophilia.

When you bleed, your body normally pools blood cells together to form a clot to stop the bleeding. The clotting process is encouraged by certain blood particles (platelets and plasma proteins). Hemophilia occurs when you have a deficiency in one of these clotting factors.

Hemophilia is inherited. However, about 30 percent of people with hemophilia have no family history of the disorder. In these people hemophilia is caused by a genetic change (spontaneous mutation).

There are several types of hemophilia. They are classified according to which clotting factor is deficient:

  • Hemophilia A, the most common type, is caused by insufficient clotting factor VIII.
  • Hemophilia B, the second most common type, is caused by insufficient clotting factor IX.
  • Hemophilia C, in which signs and symptoms are often mild, is caused by insufficient clotting factor XI.

Hemophilia inheritance

Everyone has two sex chromosomes, one from each parent. A female inherits an X chromosome from her mother and an X chromosome from her father. A male inherits an X chromosome from his mother and a Y chromosome from his father.

Hemophilia inheritance depends on your type of hemophilia:

  • Hemophilia A or B. The gene that causes them is located on the X chromosome, so it can't be passed from father to son. Hemophilia A or B almost always occurs in boys and is passed from mother to son through one of the mother's genes. Most women with the defective gene are simply carriers and experience no signs or symptoms of hemophilia. Women can experience bleeding symptoms if their factor VIII or IX is moderately decreased.
  • Hemophilia C. This disorder can be passed on to children by either parent. Hemophilia C can occur in girls and boys.

Complications of hemophilia may include:

  • Deep internal bleeding. Bleeding that occurs in deep muscle can cause your limbs to swell. The swelling may press on nerves and lead to numbness or pain.
  • Damage to joints. Internal bleeding may also put pressure on your joints, causing severe pain. Left untreated, frequent internal bleeding may cause arthritis or destruction of the joint.
  • Infection. People with hemophilia are likelier to have blood transfusions, increasing their risk of receiving contaminated blood products. Blood products became safer after the mid-1980s due to screening of donated blood for hepatitis and human immunodeficiency virus (HIV). The risk of infection through blood products also has decreased substantially since the introduction of genetically engineered clotting products (recombinant factor concentrates).
  • Adverse reaction to clotting factor treatment. In some people with hemophilia, the immune system has a negative reaction to the clotting factors used to treat bleeding. When this happens, the immune system develops proteins (known as inhibitors) that inactivate the clotting factors, making treatment less effective.

Hemophilia is diagnosed at an average age of 9 months and almost always by age 2. You and your child may be referred to a doctor who specializes in blood disorders (hematologist).

What you can do

  • Write down the symptoms your child has been experiencing, and for how long.
  • Write down your child's key medical information, including other conditions.
  • Make a list of all your child's medications, vitamins and supplements.
  • Note whether anyone in your family has been diagnosed with a bleeding disorder.

Questions to ask your child's doctor

  • What's the most likely cause of my child's signs and symptoms?
  • What kinds of tests does my child need? Do they require any special preparation?
  • What treatment do you recommend?
  • What activity restrictions will my child need to follow?
  • What additional steps can I take to ensure my child's safety?
  • What can I do to help my child live as normally as possible?
  • How will you monitor my child's health over time?
  • What is my child's risk of long-term complications?
  • Do you recommend that our family meet with a genetic counselor?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask other questions during your appointment.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may make time to go over points you want to spend more time on. You may be asked:

  • What are your child's symptoms, and when did you first notice them?
  • Have you noticed any unusual or heavy bleeding, such as nosebleeds or prolonged bleeding from a cut or vaccination?
  • Have you noticed blood in your child's urine or stool?
  • Has your child undergone any surgeries, and, if so, did the surgeon feel there was excessive bleeding?
  • Have you noticed heavy bruises?
  • Has your child complained of pain or warmth around his or her joints?
  • Has anyone in your family been diagnosed with a bleeding disorder?
  • Are you planning to have more children?

For people with a family history of hemophilia, it's possible to determine during pregnancy if the fetus is affected by hemophilia. However, the testing poses some risks to the fetus. Discuss the benefits and risks of testing with your doctor.

In children and adults, a blood test can show a clotting-factor deficiency. Hemophilia is diagnosed at an average age of 9 months and almost always by age 2. Sometimes, mild hemophilia isn't diagnosed until a person undergoes surgery and experiences excessive bleeding.

While there's no cure for hemophilia, most people with the disease can lead fairly normal lives.

Treatment for bleeding episodes

Therapies to stop bleeding depend on the type of hemophilia:

  • Mild hemophilia A. Slow injection of the hormone desmopressin (DDAVP) into a vein can stimulate a release of more clotting factor to stop bleeding. Occasionally, DDAVP is given as a nasal medication.
  • Moderate to severe hemophilia A or hemophilia B. Bleeding may stop only after an infusion of recombinant clotting factor or clotting factor derived from donated human blood. Repeated infusions may be needed if internal bleeding is severe.
  • Hemophilia C. Clotting factor XI, the factor missing in this type of hemophilia, is available only in Europe. In the United States, plasma infusions are needed to stop bleeding episodes.

Ongoing treatment

Your doctor may recommend:

  • Regular infusions of DDAVP or clotting factor. The infusions can help prevent bleeding. This approach may reduce time spent in the hospital and limit side effects such as damage to joints. Your doctor can show you how to perform the infusions.
  • Clot-preserving medications (antifibrinolytics). These medications help prevent clots from breaking down.
  • Fibrin sealants. These medications can be applied directly to wound sites to promote clotting and healing. Fibrin sealants are especially useful in dental therapy.
  • Physical therapy. It can ease signs and symptoms if internal bleeding has damaged your joints. If internal bleeding has caused severe damage, you may need surgery.
  • First aid for minor cuts. Using pressure and a bandage will generally take care of the bleeding. For small areas of bleeding beneath the skin, use an ice pack. Ice pops can be used to slow down minor bleeding in the mouth.
  • Vaccinations. Although blood products are screened, it's still possible for people who rely on them to contract diseases. If you have hemophilia, consider receiving immunization against hepatitis A and B.

To avoid excessive bleeding and protect your joints:

  • Exercise regularly. Activities such as swimming, bicycle riding and walking can build up muscles while protecting joints. Contact sports — such as football, hockey or wrestling — are not safe for people with hemophilia.
  • Avoid certain pain medications. Drugs that can aggravate bleeding include aspirin and ibuprofen (Advil, Motrin, others). Instead, use acetaminophen (Tylenol, others), which is a safe alternative for mild pain relief.
  • Avoid blood-thinning medications. Medications that prevent blood from clotting include heparin, warfarin (Coumadin), clopidogrel (Plavix) and prasugrel (Effient).
  • Practice good dental hygiene. The goal is to prevent tooth extraction, which can lead to excessive bleeding.
  • Protect your child from injuries that could cause bleeding. Kneepads, elbow pads, helmets and safety belts all may help prevent injuries from falls and other accidents. Keep your home free of furniture with sharp corners.

To help you and your child cope with hemophilia:

  • Get a medical alert bracelet. This bracelet lets medical personnel know that you or your child has hemophilia, and the type of clotting factor that's best in case of an emergency.
  • Talk with a counselor. You may be concerned about striking the right balance between keeping your child safe and encouraging as much normal activity as possible. A social worker or therapist with knowledge of hemophilia can help you cope with your concerns and identify the minimum limitations necessary for your child.
  • Let people know. Be sure to tell anyone who will be taking care of your child — baby sitters, workers at your child care center, relatives, friends and teachers — about your child's condition. If your child plays noncontact sports, be sure to tell coaches, too.
  • Experience. Every year, Mayo Clinic specialists treat more than 170 people with this rare condition.
  • Expertise. Hemophilia is rare, so it's vital to get an accurate diagnosis and treatment. Mayo Clinic has been designated a Comprehensive Hemophilia Center with doctors who specialize in the diagnosis and treatment of hemophilia.
  • Genetic testing and counseling. Mayo Clinic performs genetic testing and counseling for hemophilia and other bleeding disorders.
  • New ideas. Mayo Clinic researchers are studying ways to improve the treatment of hemophilia. You have access to Mayo's clinician-researchers.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.

Why Choose Mayo Clinic

What Sets Mayo Clinic Apart

Mayo Clinic is a designated Comprehensive Hemophilia Center (HTC), with physicians who specialize in the diagnosis and treatment of hemophilia and other bleeding disorders. People who get care at an HTC are less likely than those who get care elsewhere to have bleeding complications and hospitalizations. At Mayo Clinic, doctors, nurses, social workers and physical therapists work together to reduce hospitalizations and to improve your quality of life.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Specialists in hematology/oncology diagnose and treat adults with hemophilia.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Specialists in hematology/oncology diagnose and treat adults with hemophilia.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Specialists in hematology diagnose and treat children and adults with hemophilia.

The Division of Pediatric Hematology/Oncology at Mayo Clinic specializes in treating children with hemophilia and other bleeding disorders, coordinating care with Mayo's Comprehensive Hemophilia Center.

Read more about research in the Mayo Clinic Division of Hematology.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

Specialists in Division of Pediatric Hematology/Oncology diagnose and treat children with hemophilia.

The Division of Pediatric Hematology/Oncology at Mayo Clinic specializes in treating children with hemophilia and other bleeding disorders, coordinating care with Mayo's Comprehensive Hemophilia Center.

  • Phone: 507-284-1148, 8 a.m. to 5 p.m. Central time, Monday through Friday
  • Fax: 507-538-3517
  • Email: pedsapptoff@mayo.edu
  • Or, you can call the Mayo Clinic Children's Center at 855-MAYO-KID (855-629-6543, toll-free) from 7 a.m. to 6 p.m. Central time, Monday through Friday, or complete an online appointment request form.

See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.

Mayo Clinic researchers are working to improve treatment of hemophilia. As people with hemophilia live longer, Mayo researchers are studying ways to manage their age-related illnesses, such as heart disease. Mayo researchers are also studying the molecular genetics of hemophilia.

See a list of publications by Mayo Clinic doctors and researchers on hemophilia on PubMed, a service of the National Library of Medicine.

Sep. 26, 2014