Complications of hemophilia may include:
Sept. 26, 2014
- Deep internal bleeding. Bleeding that occurs in deep muscle can cause your limbs to swell. The swelling may press on nerves and lead to numbness or pain.
- Damage to joints. Internal bleeding may also put pressure on your joints, causing severe pain. Left untreated, frequent internal bleeding may cause arthritis or destruction of the joint.
- Infection. People with hemophilia are likelier to have blood transfusions, increasing their risk of receiving contaminated blood products. Blood products became safer after the mid-1980s due to screening of donated blood for hepatitis and human immunodeficiency virus (HIV). The risk of infection through blood products also has decreased substantially since the introduction of genetically engineered clotting products (recombinant factor concentrates).
- Adverse reaction to clotting factor treatment. In some people with hemophilia, the immune system has a negative reaction to the clotting factors used to treat bleeding. When this happens, the immune system develops proteins (known as inhibitors) that inactivate the clotting factors, making treatment less effective.
- Hoots WK, et al. Clinical manifestations and diagnosis of hemophilia. http://www.uptodate.com/home. Accessed May 12, 2014.
- AskMayoExpert. What tests are needed to confirm the diagnosis or expedite the evaluation of hemophilia? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Hoffman R, et al. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier 2013. http://www.clinicalkey.com. Accessed May 12, 2014.
- Kliegman RM, et al. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.clinicalkey.com. Accessed May 12, 2014.
- Hoots WK, et al. Treatment of hemophilia. http://www.uptodate.com/home. Accessed May 12, 2014.
- Berntorp E, et al. Modern haemophilia care. The Lancet. 2012;379:1447.
- Living with hemophilia. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/livingwith.html Accessed May 13, 2014.
- Lim MY, et al. Outcomes of management of acute coronary syndrome in patients with congenital bleeding disorders: A single center experience and review of the literature. Thrombosis Research. 2012;130:316.
- Barbara Woodward Lips Patient Education Center. Hemophilia. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2009.
- Cook, AJ. Decision Support System. Mayo Clinic, Rochester, Minn. July 17, 2014.
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