Hemolytic uremic syndrome requires treatment in the hospital. To ease immediate signs and symptoms and prevent further problems, hemolytic uremic syndrome treatment may include:
- Fluid replacement. Lost fluid and electrolytes need to be carefully replaced because the kidneys aren't removing fluids and waste as efficiently as normal.
- Red blood cell transfusions. If you don't have enough red blood cells, you may feel chilled, fatigued and short of breath. You may have a rapid heart rate, yellow skin and dark urine. Red blood cell transfusions, given through an intravenous (IV) needle, may help reverse these signs and symptoms.
- Platelet transfusions. If you're bleeding or bruising easily, platelet transfusions can help your blood clot more normally. Like red blood cell transfusions, platelet transfusions are given through an IV needle.
- Plasma exchange. Plasma is the part of blood that supports the circulation of blood cells and platelets. Sometimes a machine is used to clear the blood of its own plasma and replace it with fresh or frozen donor plasma. This process is called plasmapheresis.
- Kidney dialysis. Sometimes dialysis is needed to filter waste and excess fluid from the blood. Dialysis is usually a temporary treatment until the kidneys begin functioning adequately again. If the kidney damage is significant, however, permanent kidney failure — requiring long-term dialysis or a kidney transplant — is possible.
Despite the severity of the condition, appropriate treatment leads to a full recovery for most people with hemolytic uremic syndrome — especially young children.
In those who have some lasting kidney damage, following a low-protein diet and taking the blood pressure lowering medications known as angiotensin-converting enzyme (ACE) inhibitors if blood pressure is high may prevent or delay further kidney damage.
A less common type of hemolytic uremic syndrome called atypical hemolytic uremic syndrome also is treated with plasma exchange. The Food and Drug Administration has approved the use of a medication called eculizumab (Soliris) for the treatment of atypical hemolytic uremic syndrome. Eculizumab is a type of medication known as a monoclonal antibody. It prevents the continued destruction of healthy cells. However, this medication has a significant risk of serious infection. If possible, you or your child may receive the meningococcal vaccine before receiving this medication.
July 03, 2013
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